{"id":21330,"date":"2025-10-28T13:28:25","date_gmt":"2025-10-28T06:28:25","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=21330"},"modified":"2025-10-28T13:28:25","modified_gmt":"2025-10-28T06:28:25","slug":"macrogol-20-glycerol-monostearate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/macrogol-20-glycerol-monostearate\/","title":{"rendered":"Macrogol 20 Glycerol Monostearate"},"content":{"rendered":"

BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

Action and use<\/strong><\/p>\n

Non-ionic surfactant.<\/p>\n

Ph Eur<\/p>\n

DEFINITION<\/h2>\n

Macrogol 20 glycerol monostearate is obtained by ethoxylation with ethylene oxide of different types of glycerol stearates, mainly Glycerol monostearate 40-55 (0495). The number of moles of ethylene oxide reacted per mole of glycerol stearate is 20 (nominal value).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

Pale yellow, oily liquid or gel.<\/p>\n

Solubility<\/h3>\n

Soluble in water at 40 \u00b0C and above and in ethanol (96 per cent), practically insoluble in light liquid paraffin and in fatty oils.<\/p>\n

Relative density<\/h4>\n

About 1.07.<\/p>\n

IDENTIFICATION<\/h2>\n
    \n
  1. Hydroxyl value (see Tests).<\/li>\n
  2. Saponification value (see Tests).<\/li>\n
  3. Composition of fatty acids (see Tests).<\/li>\n
  4. Place 1 g in a test tube and add 0.1 mL of sulfuric acid R. Heat the tube until white fumes appear. The fumes turn filter paper impregnated with alkaline potassium tetraiodomercurate solution R black.<\/li>\n<\/ol>\n

    TESTS<\/h2>\n

    Acid value (2.5.1)<\/h3>\n

    Maximum 2.0, determined on 5.0 g.<\/p>\n

    Hydroxyl value (2.5.3, Method A)<\/h3>\n

    65 to 85, determined on 0.350 g.<\/p>\n

    Iodine value (2.5.4, Method A)<\/h3>\n

    Maximum 2.0.<\/p>\n

    Peroxide value (2.5.5, Method A)<\/h3>\n

    Maximum 6.0.<\/p>\n

    Saponification value (2.5.6)<\/h3>\n

    40 to 60.<\/p>\n

    Composition of fatty acids<\/h3>\n

    Gas chromatography (2.4.22, Method C).<\/p>\n

    Composition of the fatty-acid fraction of the substance:<\/p>\n\n\n\n\n\n\n
    Type of macrogol 20 glycerol monostearate<\/td>\nType of glycerol stearate used<\/td>\nComposition of fatty acids<\/td>\n<\/tr>\n
    Type I<\/td>\nType I<\/p>\n

    (obtained using stearic acid 50)<\/td>\n

    		Stearic acid: 40.0 per cent to 60.0 per cent, Sum of the contents of palmitic and stearic acids: minimum 90.0 per cent.<\/td>\n<\/tr>\n
    Type II<\/td>\nType II<\/p>\n

    (obtained using stearic acid 70)<\/td>\n

    		Stearic acid: 60.0 per cent to 80.0 per cent, Sum of the contents of palmitic and stearic acids: minimum 90.0 per cent.<\/td>\n<\/tr>\n
    Type III<\/td>\nType III<\/p>\n

    (obtained using stearic acid 95)<\/td>\n

    		Stearic acid: 90.0 per cent to 99.0 per cent, Sum of the contents of palmitic and stearic acids: minimum 96.0 per cent.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Ethylene oxide and dioxan (2.4.25, Method A)<\/h3>\n

    Maximum 1 ppm of ethylene oxide and maximum 10 ppm of dioxan.<\/p>\n

    Water (2.5.12)<\/h3>\n

    Maximum 3.0 per cent, determined on 1.00 g.<\/p>\n

    Total ash (2.4.16)<\/h3>\n

    Maximum 0.2 per cent.<\/p>\n

    STORAGE<\/h2>\n

    Protected from light.<\/p>\n

    LABELLING<\/h2>\n

    The label states the type of macrogol 20 glycerol monostearate.<\/p>\n

    Ph Eur<\/p>\n","protected":false},"excerpt":{"rendered":"

    BP 2025 (Ph. Eur. 11.6 update) Action and use Non-ionic surfactant. Ph Eur DEFINITION Macrogol 20 glycerol monostearate is obtained by ethoxylation with ethylene oxide of different types of glycerol stearates, mainly Glycerol monostearate 40-55 (0495). The number of moles of ethylene oxide reacted per mole of glycerol stearate is 20 (nominal value). CHARACTERS Appearance…<\/p>\n","protected":false},"author":5,"featured_media":21331,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-21330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/21330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=21330"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/21330\/revisions"}],"predecessor-version":[{"id":21334,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/21330\/revisions\/21334"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/21331"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=21330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=21330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=21330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}