Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n
Paraldehyde Injection is Paraldehyde that has been sterilised. It does not contain any added antimicrobial preservatives.<\/p>\n
The injection complies with the requirements stated under Parenteral Preparations and with the following requirements.<\/p>\n
A. A 10.0% v\/v solution in carbon dioxide-free water (solution A) is clear, Appendix IV A, but becomes turbid on warming.<\/p>\n
B. Heat 5 mL with 0.1 mL of 1M sulfuric acid. Acetaldehyde is evolved.<\/p>\n
C. To 5 mL of solution A in a test tube add 5 mL of ammoniacal silver nitrate solution and heat on a water bath. Silver is deposited as a mirror on the side of the tube.<\/p>\n
Titrate 50 mL of solution A with 0.1M sodium hydroxide VS using 0.05 mL of phenolphthalein solution as indicator. Not more than 1.5 mL of 0.1M sodium hydroxide VS is required to change the colour of the solution.<\/p>\n
Not more than 10% distils below 123\u00b0 and not less than 95% distils below 126\u00b0, Appendix V C.<\/p>\n
10\u00b0 to 13\u00b0, Appendix V B.<\/p>\n
1.403 to 1.406, Appendix V E.<\/p>\n
0.991 to 0.996, Appendix V G.<\/p>\n
Shake 5 mL with a mixture of 5 mL of ethanol (60%), 5 mL of alcoholic hydroxylamine solution and 0.2 mL of methyl orange solution. Not more than 0.8 mL of 0.5M sodium hydroxide VS is required to change the colour of the solution to pure yellow.<\/p>\n
To 50 mL of solution A in a ground-glass-stoppered flask add 5 mL of 1M sulfuric acid and 10 mL of potassium iodide solution, close the flask and allow to stand in the dark for 15 minutes. Titrate with 0.1M sodium thiosulfate VS using 1 mL of starch solution as indicator; allow to stand for 5 minutes and, if necessary, complete the titration. Not more than 2.0 mL of 0.1M sodium thiosulfate VS is required.<\/p>\n
Paraldehyde Injection should be supplied in single-dose glass ampoules sealed by fusion of the glass. It should be kept in complete darkness.<\/p>\n","protected":false},"excerpt":{"rendered":"
Edition: BP 2025 (Ph. Eur. 11.6 update) DEFINITION Paraldehyde Injection is Paraldehyde that has been sterilised. It does not contain any added antimicrobial preservatives. The injection complies with the requirements stated under Parenteral Preparations and with the following requirements. IDENTIFICATION A. A 10.0% v\/v solution in carbon dioxide-free water (solution A) is clear, Appendix IV…<\/p>\n","protected":false},"author":5,"featured_media":19852,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-19851","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/19851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=19851"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/19851\/revisions"}],"predecessor-version":[{"id":19856,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/19851\/revisions\/19856"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/19852"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=19851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=19851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=19851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}