﻿{"id":19524,"date":"2025-10-25T09:58:11","date_gmt":"2025-10-25T02:58:11","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=19524"},"modified":"2025-10-25T09:58:11","modified_gmt":"2025-10-25T02:58:11","slug":"potassium-citrate-mixture","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/potassium-citrate-mixture\/","title":{"rendered":"Potassium Citrate Mixture"},"content":{"rendered":"<p>Potassium Citrate Oral Solution<\/p>\n<h2>DEFINITION<\/h2>\n<p>Potassium Citrate Mixture is an oral solution containing 30% w\/v of Potassium Citrate and 5% w\/v of Citric Acid Monohydrate in a suitable vehicle with a lemon flavour. It is intended to be diluted with water before use.<\/p>\n<p>The mixture complies with the requirements stated under Oral Liquids and with the following requirements.<\/p>\n<h3>Content of citric acid monohydrate, C<sub>6<\/sub>H<sub>8<\/sub>O<sub>7<\/sub>, H<sub>2<\/sub>O<\/h3>\n<p>4.75 to 5.25% w\/v.<\/p>\n<h3>Content of potassium citrate, C<sub>6<\/sub>H<sub>5<\/sub>K<sub>3<\/sub>O<sub>7<\/sub>,H<sub>2<\/sub>O<\/h3>\n<p>28.5 to 31.5% w\/v.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Yields reaction A characteristic of potassium salts, Appendix VI.<\/p>\n<p>B. Yields reaction B characteristic of citrates, Appendix VI.<\/p>\n<h2>ASSAY<\/h2>\n<h3>For citric acid monohydrate<\/h3>\n<p>To 5 mL add 100 mL of water, boil, cool and titrate with carbonate-free 0.1M sodium hydroxide VS using thymol blue solution as indicator. Each mL of carbonate-free 0.1M sodium hydroxide VS is equivalent to 7.005 mg of C<sub>6<\/sub>H<sub>8<\/sub>O<sub>7<\/sub>, H<sub>2<\/sub>O.<\/p>\n<h3>For potassium citrate<\/h3>\n<p>To 1 g add 5 mL of acetic anhydride and 20 mL of anhydrous acetic acid, heat on a water bath for 20 minutes, allow to cool and carry out Method I for non-aqueous titration, Appendix VIII A, using 1-naphtholbenzein solution as indicator. Each mL of 0.1M perchloric acid VS is equivalent to 10.81 mg of C<sub>6<\/sub>H<sub>5<\/sub>K<sub>3<\/sub>O<sub>7<\/sub>,H<sub>2<\/sub>O. Determine the weight per mL of the mixture, Appendix V G, and calculate the content of C<sub>6<\/sub>H<sub>5<\/sub>K<sub>3<\/sub>O<sub>7<\/sub>,H<sub>2<\/sub>O, weight in volume.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Potassium Citrate Oral Solution DEFINITION Potassium Citrate Mixture is an oral solution containing 30% w\/v of Potassium Citrate and 5% w\/v of Citric Acid Monohydrate in a suitable vehicle with a lemon flavour. It is intended to be diluted with water before use. The mixture complies with the requirements stated under Oral Liquids and with&#8230;<\/p>\n","protected":false},"author":4,"featured_media":19529,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-19524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/19524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=19524"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/19524\/revisions"}],"predecessor-version":[{"id":19531,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/19524\/revisions\/19531"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/19529"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=19524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=19524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=19524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}