{"id":18712,"date":"2025-10-24T07:40:03","date_gmt":"2025-10-24T00:40:03","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=18712"},"modified":"2025-10-24T07:40:03","modified_gmt":"2025-10-24T00:40:03","slug":"ferric-chloride-injection","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/ferric-chloride-injection\/","title":{"rendered":"Ferric Chloride Injection"},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p>Iron Chloride Injection<\/p>\n<p>NOTE: This monograph has been developed to cover unlicensed formulations.<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Used in parenteral nutrition solutions.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Ferric Chloride Injection is a sterile solution of Ferric Chloride Hexahydrate in a suitable liquid.<\/p>\n<p>The injection complies with the requirements stated under Parenteral Preparations and with the following requirements. Where appropriate, the injection also complies with the requirements stated under Unlicensed Medicines.<\/p>\n<p><strong>Content of ferric iron, Fe(III)<\/strong><\/p>\n<p>90.0 to 110.0% of the stated amount.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>Yields reaction C characteristic of iron salts and reaction A characteristic of chlorides, Appendix VI.<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity<\/h3>\n<p>pH, 1.7 to 2.4, Appendix V L.<\/p>\n<h3>5-Hydroxymethylfurfural<\/h3>\n<p>Injections prepared in Glucose Infusion comply with the following test.<\/p>\n<p>Dilute a volume containing the equivalent of 1.0 g of glucose, C<sub>6<\/sub>H<sub>12<\/sub>O<sub>6<\/sub>, to 250 mL with water. The absorbance of the resulting solution at the maximum at 284 nm is not more than 0.25, Appendix II B.<\/p>\n<h2>ASSAY<\/h2>\n<p>Carry out the method for inductively coupled plasma-atomic emission spectrometry, Appendix II G1, using a wavelength of 238.2 nm.<\/p>\n<p>Dilute a quantity of the injection with sufficient 2% v\/v heavy metal-free nitric acid to produce a solution containing 0.001% w\/v of Fe.<\/p>\n<p>Calculate the content of Fe in the injection from a calibration curve obtained from a series of reference solutions prepared in the following manner. Dilute 1 volume of iron standard solution (0.1% Fe) to 10 volumes; dilute separate 0, 5, 10 and 20 mL quantities of the resulting solution to 100 mL with 2% v\/v heavy metal-free nitric acid.<\/p>\n<h2>LABELLING<\/h2>\n<p>The strength is stated as the equivalent amount of iron, Fe, in a suitable dose volume.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) Iron Chloride Injection NOTE: This monograph has been developed to cover unlicensed formulations. Action and use Used in parenteral nutrition solutions. DEFINITION Ferric Chloride Injection is a sterile solution of Ferric Chloride Hexahydrate in a suitable liquid. The injection complies with the requirements stated under Parenteral Preparations and&#8230;<\/p>\n","protected":false},"author":5,"featured_media":18713,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-18712","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/18712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=18712"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/18712\/revisions"}],"predecessor-version":[{"id":18716,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/18712\/revisions\/18716"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/18713"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=18712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=18712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=18712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}