{"id":17743,"date":"2025-10-22T15:36:09","date_gmt":"2025-10-22T08:36:09","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=17743"},"modified":"2025-10-22T15:36:09","modified_gmt":"2025-10-22T08:36:09","slug":"malathion-shampoo","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/malathion-shampoo\/","title":{"rendered":"Malathion Shampoo"},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Organophosphorus insecticide.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Malathion Shampoo contains Malathion in a suitable vehicle.<\/p>\n<p><em>The shampoo complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements.<\/em><\/p>\n<p><strong>Content of malathion, C<sub>10<\/sub>H<sub>19<\/sub>O<sub>6<\/sub>PS<sub>2<\/sub><\/strong><\/p>\n<p>95.0 to 105.0% of the stated amount.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>In the Assay, the chromatogram obtained with solution (1) shows a peak with the same retention time as that of the principal peak in the chromatogram obtained with solution (2).<\/p>\n<h2>TESTS<\/h2>\n<p><strong>Related substances<\/strong><\/p>\n<p>Carry out the method for liquid chromatography, Appendix III D, using the following solutions in a mixture of 1 volume of water and 3 volumes of acetonitrile (solvent A).<\/p>\n<p>(1) Dilute a quantity of the preparation being examined with sufficient solvent A to produce a solution containing 0.2% w\/v of Malathion.<\/p>\n<p>(2) Dilute 1 volume of solution (1) to 500 volumes.<\/p>\n<p>(3) 0.0002% w\/v each of malathion impurity A EPCRS and malathion impurity B EPCRS.<\/p>\n<h3>CHROMATOGRAPHIC CONDITIONS<\/h3>\n<p>(a) Use a stainless steel column (15 cm \u00d7 4.6 mm) packed with octadecylsilyl silica gel for chromatography (10 \u00b5m) (Nucleosil C18 is suitable).<\/p>\n<p>(b) Use isocratic elution and the mobile phase described below.<\/p>\n<p>(c) Use a flow rate of 1 mL per minute.<\/p>\n<p>(d) Use a column temperature 35\u00b0.<\/p>\n<p>(e) Use a detection wavelength of 210 nm.<\/p>\n<p>(f) Inject 20 \u00b5L of each solution.<\/p>\n<h3>MOBILE PHASE<\/h3>\n<p>45 volumes of acetonitrile and 55 volumes of water.<\/p>\n<p>When the chromatograms are recorded under the prescribed conditions, the relative retentions with reference to Malathion (retention time = about 16 minutes) are: impurity B = about 0.2 and impurity A = about 0.3.<\/p>\n<h3>SYSTEM SUITABILITY<\/h3>\n<p>The test is not valid unless, in the chromatogram obtained with solution (3), the resolution factor between the peaks due to impurity A and impurity B is at least 2.0.<\/p>\n<h3>LIMITS<\/h3>\n<p>In the chromatogram obtained with solution (1):<\/p>\n<p>the area of any peak corresponding to malathion impurity A is not greater than three times the area of the corresponding peak in the chromatogram obtained with solution (3) (0.3%);<\/p>\n<p>the area of any peak corresponding to malathion impurity B is not greater than the area of the corresponding peak in the chromatogram obtained with solution (3) (0.1%);<\/p>\n<p>the area of any other secondary peak is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (0.2%);<\/p>\n<p>the sum of the areas of any other secondary peaks is not greater than five times the area of the principal peak in the chromatogram obtained with solution (2) (1.0%).<\/p>\n<p>Disregard any peak with an area less than half the area of the principal peak in the chromatogram obtained with solution (3) (0.1%).<\/p>\n<h2>ASSAY<\/h2>\n<p>Carry out the method for liquid chromatography, Appendix III D, using the following solutions in a mixture of 1 volume of water and 3 volumes of acetonitrile (solvent B).<\/p>\n<p>(1) Dilute a quantity of the preparation being examined with sufficient solvent B to produce a solution containing 0.2% w\/v of Malathion.<\/p>\n<p>(2) 0.2% w\/v of malathion EPCRS.<\/p>\n<p>(3) 0.0002% w\/v each of malathion impurity A EPCRS and malathion impurity B EPCRS.<\/p>\n<h3>CHROMATOGRAPHIC CONDITIONS<\/h3>\n<p>The chromatographic conditions described under Related substances may be used.<\/p>\n<h3>SYSTEM SUITABILITY<\/h3>\n<p>The test is not valid unless, in the chromatogram obtained with solution (3), the resolution factor between the peaks due to impurity A and impurity B is at least 2.0.<\/p>\n<h3>DETERMINATION OF CONTENT<\/h3>\n<p>Calculate the content of C<sub>10<\/sub>H<sub>19<\/sub>O<sub>6<\/sub>PS<sub>2<\/sub> using the declared content of C<sub>10<\/sub>H<sub>19<\/sub>O<sub>6<\/sub>PS<sub>2<\/sub> in malathion EPCRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>Malathion Shampoo should be stored in an airtight container, protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>The impurities limited by the requirements of this monograph include those listed under Malathion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) Action and use Organophosphorus insecticide. DEFINITION Malathion Shampoo contains Malathion in a suitable vehicle. The shampoo complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements. Content of malathion, C10H19O6PS2 95.0 to 105.0% of the stated amount. IDENTIFICATION In the Assay, the chromatogram&#8230;<\/p>\n","protected":false},"author":5,"featured_media":17744,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-17743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17743","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=17743"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17743\/revisions"}],"predecessor-version":[{"id":17761,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17743\/revisions\/17761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/17744"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=17743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=17743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=17743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}