{"id":17693,"date":"2025-10-22T15:31:43","date_gmt":"2025-10-22T08:31:43","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=17693"},"modified":"2025-10-22T15:31:43","modified_gmt":"2025-10-22T08:31:43","slug":"malathion-lotion","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/malathion-lotion\/","title":{"rendered":"Malathion Lotion"},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Organophosphorus insecticide.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Malathion Lotion is a cutaneous solution. It contains Malathion in a suitable vehicle and may contain an alcohol.<\/p>\n<p><em>The lotion complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements.<\/em><\/p>\n<p><strong>Content of malathion, C<sub>10<\/sub>H<sub>19<\/sub>O<sub>6<\/sub>PS<sub>2<\/sub><\/strong><\/p>\n<p>90.0 to 110.0% of the stated amount.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>In the Assay, the chromatogram obtained with solution (1) shows a peak with the same retention time as that of the principal peak in the chromatogram obtained with solution (2).<\/p>\n<h2>TESTS<\/h2>\n<p><strong>Related substances<\/strong><\/p>\n<p>Carry out the method for liquid chromatography, Appendix III D, using the following solutions in a mixture of 1 volume of water and 3 volumes of acetonitrile (solvent A).<\/p>\n<p>(1) Dilute a quantity of the preparation being examined with sufficient solvent A to produce a solution containing 0.2% w\/v of Malathion.<\/p>\n<p>(2) Dilute 1 volume of solution (1) to 500 volumes.<\/p>\n<p>(3) 0.0002% w\/v each of malathion impurity A EPCRS and malathion impurity B EPCRS.<\/p>\n<p>(4) Dilute 1 volume of solution (2) to 2 volumes.<\/p>\n<h3>CHROMATOGRAPHIC CONDITIONS<\/h3>\n<p>(a) Use a stainless steel column (15 cm \u00d7 4.6 mm) packed with octadecylsilyl silica gel for chromatography (10 \u00b5m) (Nucleosil C18 is suitable).<\/p>\n<p>(b) Use isocratic elution and the mobile phase described below.<\/p>\n<p>(c) Use flow rate of 1 mL per minute.<\/p>\n<p>(d) Use a column temperature 35\u00b0.<\/p>\n<p>(e) Use a detection wavelength of 210 nm.<\/p>\n<p>(f) Inject 20 \u00b5L of each solution.<\/p>\n<h3>MOBILE PHASE<\/h3>\n<p>45 volumes of acetonitrile and 55 volumes of water.<\/p>\n<p>When the chromatograms are recorded under the prescribed conditions, the relative retentions with reference to Malathion (retention time = about 16 minutes) are: impurity B = about 0.2 and impurity A = about 0.3.<\/p>\n<h3>SYSTEM SUITABILITY<\/h3>\n<p>The test is not valid unless, in the chromatogram obtained with solution (3), the resolution factor between the peaks due to impurity A and impurity B is at least 2.0.<\/p>\n<h3>LIMITS<\/h3>\n<p>In the chromatogram obtained with solution (1):<\/p>\n<p>the area of any peak corresponding to malathion impurity A is not greater than three times the area of the corresponding peak in the chromatogram obtained with solution (3) (0.3%);<\/p>\n<p>the area of any peak corresponding to malathion impurity B is not greater than the area of the corresponding peak in the chromatogram obtained with solution (3) (0.1%);<\/p>\n<p>the area of any other secondary peak is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (0.2%);<\/p>\n<p>the sum of the areas any other secondary peaks is not greater than five times the area of the principal peak in the chromatogram obtained with solution (2) (1.0%).<\/p>\n<p>Disregard any peak with an area less than the area of the principal peak in the chromatogram obtained with solution (4) (0.1%).<\/p>\n<h2>ASSAY<\/h2>\n<p>Carry out the method for liquid chromatography, Appendix III D, using the following solutions in a mixture of 1 volume of water and 3 volumes of acetonitrile (solvent B).<\/p>\n<p>(1) Dilute a quantity of the preparation being examined with sufficient solvent B to produce a solution containing 0.2% w\/v of Malathion.<\/p>\n<p>(2) 0.2% w\/v of malathion EPCRS.<\/p>\n<p>(3) 0.0002% w\/v each of malathion impurity A EPCRS and malathion impurity B EPCRS.<\/p>\n<h3>CHROMATOGRAPHIC CONDITIONS<\/h3>\n<p>The chromatographic conditions described under Related substances may be used.<\/p>\n<h3>SYSTEM SUITABILITY<\/h3>\n<p>The test is not valid unless, in the chromatogram obtained with solution (3), the resolution factor between the peaks due to impurity A and impurity B is at least 2.0.<\/p>\n<h3>DETERMINATION OF CONTENT<\/h3>\n<p>Calculate the content of C<sub>10<\/sub>H<sub>19<\/sub>O<sub>6<\/sub>PS<sub>2<\/sub> using the declared content of C<sub>10<\/sub>H<sub>19<\/sub>O<sub>6<\/sub>PS<sub>2<\/sub> in malathion EPCRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>Malathion Lotion should be stored in an airtight container, protected from light.<\/p>\n<h2>LABELLING<\/h2>\n<p>The solution may be flammable.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>The impurities limited by the requirements of this monograph include those listed under Malathion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) Action and use Organophosphorus insecticide. DEFINITION Malathion Lotion is a cutaneous solution. It contains Malathion in a suitable vehicle and may contain an alcohol. The lotion complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements. Content of malathion, C10H19O6PS2 90.0 to 110.0%&#8230;<\/p>\n","protected":false},"author":5,"featured_media":17725,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-17693","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=17693"}],"version-history":[{"count":1,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17693\/revisions"}],"predecessor-version":[{"id":17742,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17693\/revisions\/17742"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/17725"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=17693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=17693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=17693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}