{"id":17692,"date":"2025-10-22T15:09:11","date_gmt":"2025-10-22T08:09:11","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=17692"},"modified":"2025-10-22T15:09:11","modified_gmt":"2025-10-22T08:09:11","slug":"meptazinol-tablets","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/meptazinol-tablets\/","title":{"rendered":"Meptazinol Tablets"},"content":{"rendered":"<p><strong>Action and use<\/strong><\/p>\n<p>Opioid receptor partial agonist; analgesic.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Meptazinol Tablets contain Meptazinol Hydrochloride.<\/p>\n<p>The tablets comply with the requirements stated under Tablets and with the following requirements.<\/p>\n<h3>Content of meptazinol, C<sub>15<\/sub>H<sub>23<\/sub>NO<\/h3>\n<p>95.0 to 105.0% of the stated amount.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. The light absorption, Appendix II B, in the range 220 to 330 nm of the solution obtained in the Assay exhibits a maximum at 273 nm.<\/p>\n<p>B. Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions in ethanol (96%).<\/p>\n<p>(1) Shake a quantity of the powdered tablets containing the equivalent of 50 mg of meptazinol with 5 mL of ethanol (96%), centrifuge and dilute 1 volume of the supernatant liquid to 50 volumes with ethanol (96%).<\/p>\n<p>(2) 0.02% w\/v of meptazinol hydrochloride BPCRS in ethanol (96%).<\/p>\n<p>CHROMATOGRAPHIC CONDITIONS<\/p>\n<p>(a) Use as the coating silica gel F254 (Merck silica gel 60 F254 plates are suitable).<\/p>\n<p>(b) Use the mobile phase as described below.<\/p>\n<p>(c) Apply 10 \u03bcL of each solution.<\/p>\n<p>(d) Develop the plate to 15 cm.<\/p>\n<p>(e) After removal of the plate, dry in air and examine under ultraviolet light (254 nm).<\/p>\n<p>MOBILE PHASE<\/p>\n<p>1 volume of 18M ammonia, 20 volumes of absolute ethanol and 79 volumes of toluene.<\/p>\n<p>CONFIRMATION<\/p>\n<p>The principal spot in the chromatogram obtained with solution (1) corresponds in intensity, position and size to that in the chromatogram obtained with solution (2).<\/p>\n<h2>TESTS<\/h2>\n<h3>Related substances<\/h3>\n<p>Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions in ethanol (96%).<\/p>\n<p>(1) Shake a quantity of the powdered tablets containing the equivalent of 0.2 g of meptazinol with 20 mL of ethanol (96%), centrifuge and use the supernatant liquid.<\/p>\n<p>(2) Dilute 1 volume of solution (1) to 100 volumes.<\/p>\n<p>(3) Dilute 1 volume of solution (2) to 2 volumes.<\/p>\n<p>CHROMATOGRAPHIC CONDITIONS<\/p>\n<p>(a) Use as the coating silica gel (Merck silica gel 60 F254 plates are suitable).<\/p>\n<p>(b) Use the mobile phase as described below.<\/p>\n<p>(c) Apply 10 \u03bcL of each solution.<\/p>\n<p>(d) Develop the plate to 15 cm.<\/p>\n<p>(e) After removal of the plate, dry in air, examine under ultraviolet light (254 nm), expose to iodine vapour for 2 hours and examine again.<\/p>\n<p>MOBILE PHASE<\/p>\n<p>1 volume of 18M ammonia, 30 volumes of chloroform and 70 volumes of ethyl acetate.<\/p>\n<p>LIMITS<\/p>\n<p>By each method of visualisation, any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (1%) and not more than one such spot is more intense than the spot in the chromatogram obtained with solution (3) (0.5%).<\/p>\n<h2>ASSAY<\/h2>\n<p>To a quantity of the powdered tablets containing the equivalent of 0.2 g of meptazinol add 40 mL of 0.06M hydrochloric acid, shake, dilute to 50 mL with the same solvent, filter through a glass-fibre paper (Whatman GF\/C paper is suitable); dilute 5 mL of the filtrate to 250 mL with 0.06M hydrochloric acid and measure the absorbance of the resulting solution at the maximum at 273 nm, Appendix II B. Calculate the content of C<sub>15<\/sub>H<sub>23<\/sub>NO from the absorbance obtained using a 0.0080% w\/v solution of meptazinol hydrochloride BPCRS in 0.06M hydrochloric acid and from the declared content of C<sub>15<\/sub>H<sub>23<\/sub>NO in meptazinol hydrochloride BPCRS.<\/p>\n<h2>LABELLING<\/h2>\n<p>The quantity of active ingredient is stated in terms of the equivalent amount of meptazinol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Action and use Opioid receptor partial agonist; analgesic. DEFINITION Meptazinol Tablets contain Meptazinol Hydrochloride. The tablets comply with the requirements stated under Tablets and with the following requirements. Content of meptazinol, C15H23NO 95.0 to 105.0% of the stated amount. IDENTIFICATION A. The light absorption, Appendix II B, in the range 220 to 330 nm of&#8230;<\/p>\n","protected":false},"author":2,"featured_media":17696,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-17692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17692","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=17692"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17692\/revisions"}],"predecessor-version":[{"id":17699,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17692\/revisions\/17699"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/17696"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=17692"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=17692"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=17692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}