{"id":17224,"date":"2025-10-22T09:13:33","date_gmt":"2025-10-22T02:13:33","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=17224"},"modified":"2025-10-22T09:27:15","modified_gmt":"2025-10-22T02:27:15","slug":"lacosamide","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/lacosamide\/","title":{"rendered":"Lacosamide"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 2992)<\/em><\/p>\n<p>C<sub>13<\/sub>H<sub>18<\/sub>N<sub>2<\/sub>O<sub>3<\/sub> 250.3 175481-36-4<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Antiepileptic.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Lacosamide Infusion<\/p>\n<p>Lacosamide Oral Solution<\/p>\n<p>Lacosamide Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>(2R)-2-Acetamido-N-benzyl-3-methoxypropanamide.<\/p>\n<h3>Content<\/h3>\n<p>98.0 per cent to 102.0 per cent (anhydrous substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white or light yellow powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Sparingly soluble in water, freely soluble in methanol, practically insoluble in heptane.<\/p>\n<p>It shows polymorphism (5.9).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>Carry out either tests A, B or tests B, C.<\/p>\n<p>A. Specific optical rotation (2.2.7): + 14 to + 18 (anhydrous substance), measured at 25 \u00b0C.<\/p>\n<p>Dissolve 0.100 g in methanol R and dilute to 10.0 mL with the same solvent.<\/p>\n<p>B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: lacosamide CRS.<\/p>\n<p>If the spectra obtained in the solid state show differences, dissolve the substance to be examined and the reference substance separately in methanol R, evaporate to dryness and record new spectra using the residues.<\/p>\n<p>C. Enantiomeric purity (see Tests).<\/p>\n<h2>TESTS<\/h2>\n<h3>Appearance of solution<\/h3>\n<p>The solution is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n<p>Dissolve 0.500 g in water R and dilute to 50.0 mL with the same solvent.<\/p>\n<h3>Enantiomeric purity<\/h3>\n<p>Liquid chromatography (2.2.29): use the normalisation procedure.<\/p>\n<p>Test solution: Dissolve 50.0 mg of the substance to be examined in the mobile phase and dilute to 50.0 mL with the mobile phase.<\/p>\n<p>Reference solution (a): Dissolve 1 mg of lacosamide impurity A CRS in the mobile phase and dilute to 10.0 mL with the mobile phase.<\/p>\n<p>Reference solution (b): Dissolve 20 mg of the substance to be examined in the mobile phase, add 1.0 mL of reference solution (a) and dilute to 20.0 mL with the mobile phase.<\/p>\n<p>Reference solution (c): Dilute 1.0 mL of the test solution to 100.0 mL with the mobile phase. Dilute 1.0 mL of this solution to 20.0 mL with the mobile phase.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.25 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: amylose derivative of silica gel for chiral separation R (10 \u03bcm).<\/p>\n<p>Mobile phase: water for chromatography R, 2-propanol R, heptane R (3:100:900 V\/V\/V).<\/p>\n<p>Flow rate: 1.0 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 215 nm.<\/p>\n<p>Injection: 20 \u03bcL of the test solution and reference solutions (b) and (c).<\/p>\n<p>Run time: 1.7 times the retention time of lacosamide.<\/p>\n<p>Identification of impurities: Use the chromatogram obtained with reference solution (b) to identify the peak due to impurity A.<\/p>\n<p>Relative retention: With reference to lacosamide (retention time = about 25 min): impurity A = about 0.8.<\/p>\n<p>System suitability: Reference solution (b):<\/p>\n<p>\u2014 resolution: minimum 3.0 between the peaks due to impurity A and lacosamide.<\/p>\n<p>Limit:<\/p>\n<p>\u2014 impurity A: maximum 0.15 per cent;<\/p>\n<p>\u2014 reporting threshold: 0.05 per cent (reference solution (c)).<\/p>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29).<\/p>\n<p>Test solution: Dissolve 50.0 mg of the substance to be examined in 1 mL of methanol R and dilute to 10.0 mL with water R.<\/p>\n<p>Reference solution (a): Dissolve 50.0 mg of lacosamide CRS in 1 mL of methanol R and dilute to 10.0 mL with water R.<\/p>\n<p>Reference solution (b): Dilute 1.0 mL of the test solution to 100.0 mL with a mixture of 10 volumes of methanol R and 90 volumes of water R. Dilute 1.0 mL of this solution to 10.0 mL with the same mixture of solvents.<\/p>\n<p>Reference solution (c): Dissolve 5 mg of lacosamide for system suitability CRS (containing impurities B, C, G and I) in 0.1 mL of methanol R and dilute to 1.0 mL with water R.<\/p>\n<p>Reference solution (d): Dissolve 1 mg of lacosamide impurity F CRS in 2 mL of methanol R and dilute to 10.0 mL with water R. Dilute 1.0 mL of the solution to 10.0 mL with water R.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.15 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: end-capped extra-dense bonded octylsilyl silica gel for chromatography R (3.5 \u03bcm).<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: 0.1 per cent V\/V solution of trifluoroacetic acid R;<\/p>\n<p>\u2014 mobile phase B: trifluoroacetic acid R, acetonitrile R, methanol R (0.3:500:500 V\/V\/V);<\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 148px;\">\n<tbody>\n<tr style=\"height: 43px;\">\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0 &#8211; 2<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">89<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">11<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">2 &#8211; 14.2<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">89 \u2192 69<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">11 \u2192 31<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">14.2 &#8211; 19.5<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">69 \u2192 23<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">31 \u2192 77<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">19.5 &#8211; 20<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">23 \u2192 0<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">77 \u2192 100<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">20 &#8211; 21<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">100<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 1.2 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 258 nm.<\/p>\n<p>Injection: 20 \u03bcL of the test solution and reference solutions (b), (c) and (d).<\/p>\n<p>Identification of impurities: Use the chromatogram supplied with lacosamide for system suitability CRS and the chromatogram obtained with reference solution (c) to identify the peaks due to impurities B, C, G and I; use the chromatogram obtained with reference solution (d) to identify the peak due to impurity F.<\/p>\n<p>Relative retention: With reference to lacosamide (retention time = about 12 min): impurity F = about 0.7; impurity G = about 0.9; impurity B = about 1.2; impurity C = about 1.3; impurity I = about 1.6.<\/p>\n<p>System suitability: Reference solution (c):<\/p>\n<p>\u2014 resolution: minimum 2.0 between the peaks due to impurity G and lacosamide; minimum 4.5 between the peaks due to lacosamide and impurity B.<\/p>\n<p>Calculation of percentage contents:<\/p>\n<p>\u2014 correction factors: multiply the peak areas of the following impurities by the corresponding correction factor: impurity G = 0.7; impurity I = 0.7;<\/p>\n<p>\u2014 for each impurity, use the concentration of lacosamide in reference solution (b).<\/p>\n<p>Limits:<\/p>\n<p>\u2014 impurities B, C, F, G, I: for each impurity, maximum 0.15 per cent;<\/p>\n<p>\u2014 unspecified impurities: for each impurity, maximum 0.10 per cent;<\/p>\n<p>\u2014 total: maximum 0.5 per cent;<\/p>\n<p>\u2014 reporting threshold: 0.05 per cent.<\/p>\n<h3>Water (2.5.32)<\/h3>\n<p>Maximum 0.2 per cent, determined on 0.150 g by direct sample introduction.<\/p>\n<h3>Sulfated ash (2.4.14)<\/h3>\n<p>Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29) as described in the test for related substances with the following modifications.<\/p>\n<p>Injection: Test solution and reference solution (a).<\/p>\n<p>System suitability Reference solution (a):<\/p>\n<p>\u2014 symmetry factor: maximum 2.4 for the peak due to lacosamide.<\/p>\n<p>Calculate the percentage content of C<sub>13<\/sub>H<sub>18<\/sub>N<sub>2<\/sub>O<sub>3<\/sub> taking into account the assigned content of lacosamide CRS.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C, F, G, I.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) D, E, H, J, K.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17280\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-259-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-259-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-259-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-259-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-259.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. (2S)-2-acetamido-N-benzyl-3-methoxypropanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17281\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-242-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-242-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-242-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-242-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-242.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. (2\u039e)-2-acetamido-3-(benzylamino)-3-oxopropyl acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17282\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-221-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-221-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-221-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-221-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-221.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. (2\u039e)-N-benzyl-3-methoxy-2-(N-methylacetamido)propanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17283\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-179-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-179-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-179-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-179-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-179.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>D. (2\u039e)-2-amino-N-benzyl-3-methoxypropanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17284\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-141-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-141-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-141-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-141-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-141.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. (2\u039e)-2-amino-N-benzyl-3-hydroxypropanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17285\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-118-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-118-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-118-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-118-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-118.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. (2\u039e)-2-acetamido-N-benzyl-3-hydroxypropanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17286\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-90-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-90-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-90-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-90-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-90.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. N-benzylacetamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17287\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-65-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-65-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-65-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-65-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-65.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. (2\u039e)-2-acetamido-N-[(2\u039e)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]-3-methoxypropanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17288\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-56-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-56-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-56-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-56-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-56.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. (2\u039e)-N-benzyl-2-[(benzylcarbamoyl)amino]-3-methoxypropanamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17289\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-43-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-43-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-43-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-43-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-43.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. phenylmethanamine,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-17290\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/12-26-300x163.jpg\" alt=\"Lacosamide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/12-26-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/12-26-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/12-26-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/12-26.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>K. 2-acetamido-N-benzylprop-2-enamide.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 2992) C13H18N2O3 250.3 175481-36-4 Action and use Antiepileptic. Preparations Lacosamide Infusion Lacosamide Oral Solution Lacosamide Tablets DEFINITION (2R)-2-Acetamido-N-benzyl-3-methoxypropanamide. Content 98.0 per cent to 102.0 per cent (anhydrous substance). CHARACTERS Appearance White or almost white or light yellow powder. Solubility Sparingly soluble in water, freely soluble in methanol, practically insoluble in heptane. It&#8230;<\/p>\n","protected":false},"author":4,"featured_media":17279,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-17224","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=17224"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17224\/revisions"}],"predecessor-version":[{"id":17293,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/17224\/revisions\/17293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/17279"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=17224"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=17224"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=17224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}