{"id":16448,"date":"2025-10-21T10:10:04","date_gmt":"2025-10-21T03:10:04","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=16448"},"modified":"2025-11-15T16:05:11","modified_gmt":"2025-11-15T09:05:11","slug":"iodinated-povidone","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/iodinated-povidone\/","title":{"rendered":"Iodinated Povidone"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 1142)<\/em><\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Antiseptic.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Povidone-Iodine Eye Drops<\/p>\n<p>Povidone-Iodine Mouthwash<\/p>\n<p>Povidone-Iodine Solution<\/p>\n<h2>DEFINITION<\/h2>\n<p>Complex of iodine and povidone.<\/p>\n<h3>Content<\/h3>\n<p>9.0 per cent to 12.0 per cent of available iodine (dried substance).<\/p>\n<h2>PRODUCTION<\/h2>\n<p>It is produced using povidone that complies with the monograph on Povidone (0685), except that the povidone used may contain not more than 2.0 per cent of formic acid and not more than 8.0 per cent of water.<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>Yellowish-brown or reddish-brown, amorphous powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Soluble in water and in ethanol (96 per cent), practically insoluble in acetone.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: iodinated povidone CRS.<\/p>\n<p>B. Dissolve 10 mg in 10 mL of water R and add 1 mL of starch solution R. An intense blue colour is produced.<\/p>\n<h2>TESTS<\/h2>\n<h3>pH (2.2.3)<\/h3>\n<p>1.5 to 5.0.<\/p>\n<p>Dissolve 1.0 g in 10 mL of carbon dioxide-free water R.<\/p>\n<h3>Iodide<\/h3>\n<p>Maximum 6.0 per cent (dried substance).<\/p>\n<p>Dissolve 0.500 g in 100 mL of water R. Add sodium metabisulfite R until the colour of the iodine has disappeared. Add 25.0 mL of 0.1 M silver nitrate, 10 mL of nitric acid R and 5 mL of ferric ammonium sulfate solution R2. Titrate with 0.1 M ammonium thiocyanate. Carry out a blank titration.<\/p>\n<p>1 mL of 0.1 M silver nitrate is equivalent to 12.69 mg of total iodine. From the percentage of total iodine, calculated with reference to the dried substance, subtract the percentage of available iodine as determined in the assay to obtain the percentage of iodide.<\/p>\n<h3>Loss on drying (2.2.32)<\/h3>\n<p>Maximum 8.0 per cent, determined on 0.500 g by drying in an oven at 105 \u00b0C for 3 h.<\/p>\n<h3>Sulfated ash (2.4.14)<\/h3>\n<p>Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Transfer 1.000 g into a ground-glass-stoppered flask containing 150 mL of water R and stir for 1 h. Add 0.1 mL of dilute acetic acid R and titrate with 0.1 M sodium thiosulfate using starch solution R as indicator.<\/p>\n<p>1 mL of 0.1 M sodium thiosulfate is equivalent to 12.69 mg of available iodine.<\/p>\n<h2>STORAGE<\/h2>\n<p>Protected from light.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 1142) Action and use Antiseptic. Preparations Povidone-Iodine Eye Drops Povidone-Iodine Mouthwash Povidone-Iodine Solution DEFINITION Complex of iodine and povidone. Content 9.0 per cent to 12.0 per cent of available iodine (dried substance). PRODUCTION It is produced using povidone that complies with the monograph on Povidone (0685), except that the povidone used may&#8230;<\/p>\n","protected":false},"author":4,"featured_media":16714,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-16448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=16448"}],"version-history":[{"count":1,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16448\/revisions"}],"predecessor-version":[{"id":16453,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16448\/revisions\/16453"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/16714"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=16448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=16448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=16448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}