{"id":16419,"date":"2025-10-21T10:00:33","date_gmt":"2025-10-21T03:00:33","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=16419"},"modified":"2025-10-21T10:00:33","modified_gmt":"2025-10-21T03:00:33","slug":"lactic-acid","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/lactic-acid\/","title":{"rendered":"Lactic Acid"},"content":{"rendered":"<p>(Ph. Eur. monograph 0458)<\/p>\n<p>C<sub>3<\/sub>H<sub>6<\/sub>O<sub>3<\/sub>\u00a0 \u00a0 \u00a0 \u00a0 90.1<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Sodium Lactate Infusion<\/p>\n<p>Compound Sodium Lactate Infusion<\/p>\n<p>Lactic Acid Pessaries<\/p>\n<h2>DEFINITION<\/h2>\n<p>Mixture of 2-hydroxypropanoic acid, its condensation products, such as lactoyl-lactic acid and polylactic acids, and water. The equilibrium between lactic acid and polylactic acids depends on the concentration and temperature. It is usually the racemate ((RS)-lactic acid).<\/p>\n<h3>Content<\/h3>\n<p>88.0 per cent m\/m to 92.0 per cent m\/m of C<sub>3<\/sub>H<sub>6<\/sub>O<sub>3<\/sub>.<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>Colourless or slightly yellow, syrupy liquid.<\/p>\n<h3>Solubility<\/h3>\n<p>Lactic Acid<\/p>\n<p>Miscible with water and with ethanol (96 per cent).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Dissolve 1 g in 10 mL of water R. The solution is strongly acidic (2.2.4).<\/p>\n<p>B. Relative density (2.2.5): 1.20 to 1.21.<\/p>\n<p>C. It gives the reaction of lactates (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<h3>Solution S<\/h3>\n<p>Dissolve 5.0 g in 42 mL of 1 M sodium hydroxide and dilute to 50 mL with distilled water R.<\/p>\n<h3>Appearance<\/h3>\n<p>The substance to be examined is not more intensely coloured than reference solution Y<sub>6<\/sub> (2.2.2, Method II).<\/p>\n<h3>Ether-insoluble substances<\/h3>\n<p>Dissolve 1.0 g in 25 mL of ether R. The solution is not more opalescent than the solvent used for the test.<\/p>\n<h3>Sugars and other reducing substances<\/h3>\n<p>To 1 mL of solution S add 1 mL of 1 M hydrochloric acid, heat to boiling, allow to cool and add 1.5 mL of 1 M sodium hydroxide and 2 mL of cupri-tartaric solution R. Heat to boiling. No red or greenish precipitate is formed.<\/p>\n<h3>Methanol (2.4.24)<\/h3>\n<p>Maximum 50 ppm, if intended for use in the manufacture of parenteral preparations.<\/p>\n<h3>Citric, oxalic and phosphoric acids<\/h3>\n<p>To 5 mL of solution S add dilute ammonia R1 until slightly alkaline (2.2.4). Add 1 mL of calcium chloride solution R. Heat on a water-bath for 5 min. Both before and after heating, any opalescence in the solution is not more intense than that in a mixture of 1 mL of water R and 5 mL of solution S.<\/p>\n<h3>Sulfates (2.4.13)<\/h3>\n<p>Maximum 200 ppm.<\/p>\n<p>Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n<h3>Calcium (2.4.3)<\/h3>\n<p>Maximum 200 ppm.<\/p>\n<p>Dilute 5 mL of solution S to 15 mL with distilled water R.<\/p>\n<h4>Sulfated ash (2.4.14)<\/h4>\n<p>Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n<h4>Bacterial endotoxins (2.6.14)<\/h4>\n<p>Less than 5 IU\/g, if intended for use in the manufacture of parenteral preparations without a further appropriate procedure for the removal of bacterial endotoxins.<\/p>\n<p>Before use, neutralise the test solution to pH 7.0-7.5 with strong sodium hydroxide solution R and shake vigorously.<\/p>\n<h2>ASSAY<\/h2>\n<p>Place 1.000 g in a ground-glass-stoppered flask and add 10 mL of water R and 20.0 mL of 1 M sodium hydroxide. Close the flask and allow to stand for 30 min. Using 0.5 mL of phenolphthalein solution R as indicator, titrate with 1 M hydrochloric acid until the pink colour is discharged.<\/p>\n<p>1 mL of 1 M sodium hydroxide is equivalent to 90.1 mg of C<sub>3<\/sub>H<sub>6<\/sub>O<sub>3<\/sub>.<\/p>\n<h2>LABELLING<\/h2>\n<p>The label states, where applicable, that the substance is suitable for use in the manufacture of parenteral preparations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0458) C3H6O3\u00a0 \u00a0 \u00a0 \u00a0 90.1 Preparations Sodium Lactate Infusion Compound Sodium Lactate Infusion Lactic Acid Pessaries DEFINITION Mixture of 2-hydroxypropanoic acid, its condensation products, such as lactoyl-lactic acid and polylactic acids, and water. The equilibrium between lactic acid and polylactic acids depends on the concentration and temperature. It is usually the&#8230;<\/p>\n","protected":false},"author":2,"featured_media":16705,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-16419","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-volumes-1-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=16419"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16419\/revisions"}],"predecessor-version":[{"id":16422,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16419\/revisions\/16422"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/16705"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=16419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=16419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=16419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}