{"id":16335,"date":"2025-10-21T09:54:32","date_gmt":"2025-10-21T02:54:32","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=16335"},"modified":"2025-10-21T09:54:32","modified_gmt":"2025-10-21T02:54:32","slug":"indometacin","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/indometacin\/","title":{"rendered":"Indometacin"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0092)<\/em><\/p>\n<p>C<sub>19<\/sub>H<sub>16<\/sub>ClNO<sub>4<\/sub> 357.8 53-86-1<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Indometacin Capsules<\/p>\n<p>Indometacin Suppositories<\/p>\n<h2>DEFINITION<\/h2>\n[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid.<\/p>\n<h3>Content<\/h3>\n<p>98.0 per cent to 102.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or yellow, crystalline powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Practically insoluble in water, sparingly soluble in ethanol (96 per cent).<\/p>\n<p>It shows polymorphism (5.9). The acceptable crystalline form corresponds to indometacin CRS.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: A, B.<\/p>\n<p>Second identification: A, C.<\/p>\n<p>A. Melting point (2.2.14): 158 \u00b0C to 162 \u00b0C.<\/p>\n<p>B. Infrared absorption spectrophotometry (2.2.24), without recrystallisation.<\/p>\n<p>Comparison: indometacin CRS.<\/p>\n<p>C. Thin-layer chromatography (2.2.27).<\/p>\n<p>Test solution: Dissolve 10 mg of the substance to be examined in 1.0 mL of methanol R.<\/p>\n<p>Reference solution: Dissolve 10 mg of indometacin CRS in 1.0 mL of methanol R.<\/p>\n<p>Plate: TLC silica gel F254 plate R.<\/p>\n<p>Mobile phase: formic acid R, ethyl acetate R, toluene R (2:28:70 V\/V\/V).<\/p>\n<p>Application: 2 \u03bcL.<\/p>\n<p>Development: Over 3\/4 of the plate.<\/p>\n<p>Drying: In air.<\/p>\n<p>Detection A: Examine in ultraviolet light at 254 nm.<\/p>\n<p>Results A: The principal spot in the chromatogram obtained with the test solution is similar in position and size to the principal spot in the chromatogram obtained with the reference solution.<\/p>\n<p>Detection B: Spray with anisaldehyde solution R; heat the plate at 120 \u00b0C till the spots become visible (about 30 s) and examine in daylight and in ultraviolet light at 365 nm.<\/p>\n<p>Results B: The principal spot in the chromatogram obtained with the test solution is similar in position, colour in daylight, fluorescence in ultraviolet light at 365 nm and size to the principal spot in the chromatogram obtained with the reference solution.<\/p>\n<h2>TESTS<\/h2>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29). Prepare the solutions immediately before use.<\/p>\n<p>Solvent mixture acetonitrile R, water R (50:50 V\/V).<\/p>\n<p>Test solution: Dissolve 25.0 mg of the substance to be examined in the solvent mixture, using sonication if necessary, and dilute to 25.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (a): Dilute 1.0 mL of the test solution to 100.0 mL with the solvent mixture. Dilute 1.0 mL of this solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (b): Dissolve the contents of a vial of indometacin impurity mixture CRS (impurities I and J) in 1 mL of the solvent mixture.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.10 m, \u00d8 = 2.1 mm;<\/p>\n<p>\u2014 stationary phase: end-capped ethylene-bridged phenylsilyl silica gel for chromatography (hybrid material) R (1.7 \u03bcm);<\/p>\n<p>\u2014 temperature: 50 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: 5 g\/L solution of formic acid R;<\/p>\n<p>\u2014 mobile phase B: 5 g\/L solution of formic acid R in acetonitrile R;<\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 106px;\">\n<tbody>\n<tr style=\"height: 43px;\">\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0 &#8211; 5.5<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">60<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">40<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">5.5 &#8211; 5.6<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">60 \u2192 30<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">40 \u2192 70<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">5.6 &#8211; 9<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">30<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">70<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 0.3 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 254 nm.<\/p>\n<p>Injection: 1.4 \u03bcL.<\/p>\n<p>Identification of impurities: Use the chromatogram supplied with indometacin impurity mixture CRS and the chromatogram obtained with reference solution (b) to identify the peaks due to impurities I and J.<\/p>\n<p>Relative retention: With reference to indometacin (retention time = about 6 min): impurity I = about 1.3; impurity J = about 1.4.<\/p>\n<p>System suitability: Reference solution (b):<\/p>\n<p>\u2014 resolution: minimum 3.0 between the peaks due to impurities I and J.<\/p>\n<p>Calculation of percentage contents:<\/p>\n<p>\u2014 for each impurity, use the concentration of indometacin in reference solution (a).<\/p>\n<p>Limits:<\/p>\n<p>\u2014 unspecified impurities: for each impurity, maximum 0.10 per cent;<\/p>\n<p>\u2014 total: maximum 0.3 per cent;<\/p>\n<p>\u2014 reporting threshold: 0.05 per cent.<\/p>\n<h3>Loss on drying (2.2.32)<\/h3>\n<p>Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105 \u00b0C.<\/p>\n<h3>Sulfated ash (2.4.14)<\/h3>\n<p>Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29).<\/p>\n<p>Solvent mixture acetonitrile R, water R (50:50 V\/V).<\/p>\n<p>Test solution: Dissolve 25.0 mg of the substance to be examined in the solvent mixture and dilute to 25.0 mL with the solvent mixture. Dilute 1.0 mL of the solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution: Dissolve 25.0 mg of indometacin CRS in the solvent mixture and dilute to 25.0 mL with the solvent mixture. Dilute 1.0 mL of the solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.10 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: end-capped solid core octadecylsilyl silica gel for chromatography R (2.6 \u03bcm);<\/p>\n<p>\u2014 temperature: 50 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: 10 g\/L solution of acetic acid R;<\/p>\n<p>\u2014 mobile phase B: 10 g\/L solution of acetic acid R in acetonitrile R;<\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 84px;\">\n<tbody>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0 &#8211; 5<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">50<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">50<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">5 &#8211; 5.5<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">50 \u2192 0<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">50 \u2192 100<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">5.5 &#8211; 8<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">100<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 0.8 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 254 nm.<\/p>\n<p>Injection: 10 \u03bcL.<\/p>\n<p>Retention time: Indometacin = about 4 min.<\/p>\n<p>Calculate the percentage content of C<sub>19<\/sub>H<sub>16<\/sub>ClNO<sub>4<\/sub> taking into account the assigned content of indometacin CRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>Protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) A, B, C, D, E, F, G, H, I, J.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16686\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-242-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-242-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-242-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-242-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-242.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 4-chlorobenzoic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16687\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-226-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-226-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-226-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-226-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-226.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. (5-methoxy-2-methyl-1H-indol-3-yl)acetic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16688\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-206-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-206-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-206-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-206-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-206.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. 4-chloro-N-(4-methoxyphenyl)benzamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16689\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-165-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-165-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-165-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-165-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-165.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>D. [1-(2-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16690\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-129-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-129-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-129-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-129-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-129.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. [1-(3-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16691\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-107-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-107-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-107-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-107-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-107.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. 4-chloro-N\u2032-(4-chlorobenzoyl)-N-(4-methoxyphenyl)benzohydrazide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16692\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-81-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-81-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-81-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-81-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-81.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. [1-(3,4-dichlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16693\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-59-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-59-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-59-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-59-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-59.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. methyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16694\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-52-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-52-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-52-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-52-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-52.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. ethyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-16695\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-39-300x163.jpg\" alt=\"Indometacin \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-39-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-39-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-39-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-39.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. 4-chloro-N\u2032-[[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]-N-(4-methoxyphenyl)benzohydrazide.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0092) C19H16ClNO4 357.8 53-86-1 Action and use Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory. Preparations Indometacin Capsules Indometacin Suppositories DEFINITION [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid. Content 98.0 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or yellow, crystalline powder. Solubility Practically insoluble in water, sparingly soluble in ethanol (96 per cent). It shows polymorphism (5.9)&#8230;.<\/p>\n","protected":false},"author":4,"featured_media":16685,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-16335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=16335"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16335\/revisions"}],"predecessor-version":[{"id":16697,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16335\/revisions\/16697"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/16685"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=16335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=16335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=16335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}