{"id":16126,"date":"2025-10-18T17:05:14","date_gmt":"2025-10-18T10:05:14","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=16126"},"modified":"2025-10-18T17:05:49","modified_gmt":"2025-10-18T10:05:49","slug":"glucose-infusion","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/glucose-infusion\/","title":{"rendered":"Glucose Infusion"},"content":{"rendered":"

(Ph. Eur. 11.6 update)<\/p>\n

Glucose Injection<\/p>\n

Glucose Intravenous Infusion<\/p>\n

DEFINITION<\/h2>\n

Glucose Infusion is a sterile solution containing Glucose or Glucose Monohydrate. It is supplied as a ready-to-use solution.<\/p>\n

The infusion complies with the requirements stated under Parenteral Preparations and with the following requirements.<\/p>\n

Content of glucose, C6<\/sub>H12<\/sub>O6<\/sub><\/strong><\/p>\n

95.0 to 105.0% of the stated amount.<\/p>\n

CHARACTERISTICS<\/h2>\n

A colourless solution. Solutions containing the equivalent of 200 g per litre or more of glucose, C6<\/sub>H12<\/sub>O6<\/sub>, may be not more than faintly yellow in colour.<\/p>\n

IDENTIFICATION<\/h2>\n

A. Heat with cupri-tartaric solution R1. A red precipitate is produced.<\/p>\n

B. The solution prepared as directed in the Assay is dextrorotatory.<\/p>\n

TESTS<\/h2>\n

Acidity<\/strong><\/p>\n

pH, 3.5 to 6.5, Appendix V L, when determined on a solution diluted, if necessary, with water for injections, to contain not more than the equivalent of 5% w\/v of glucose, C6<\/sub>H12<\/sub>O6<\/sub>, and to which 0.30 mL of a saturated solution of potassium chloride has been added for each 100 mL of solution.<\/p>\n

5-Hydroxymethylfurfural and related substances<\/strong><\/p>\n

Dilute a volume containing the equivalent of 1.0 g of glucose, C6<\/sub>H12<\/sub>O6<\/sub>, to 250 mL with water. The absorbance of the resulting solution at the maximum at 284 nm is not more than 0.25, Appendix II B.<\/p>\n

Bacterial endotoxins<\/p>\n

The endotoxin limit concentration is 0.25 IU per mL, Appendix XIV C. Dilute infusions containing more than 5% w\/v of Glucose with water BET to contain 5% w\/v.<\/p>\n

ASSAY<\/h2>\n

To a volume containing the equivalent of 2 g to 5 g of glucose, C6<\/sub>H12<\/sub>O6<\/sub>, add 0.2 mL of 5M ammonia and sufficient water to produce 100 mL. Mix well, allow to stand for 30 minutes and determine the optical rotation in a 2-dm tube, Appendix V F. The observed rotation in degrees multiplied by 0.9477 represents the weight in g of glucose, C6<\/sub>H12<\/sub>O6<\/sub>, in the volume taken for assay.<\/p>\n

LABELLING<\/h2>\n

The strength is stated as the equivalent number of grams of glucose, C6<\/sub>H12<\/sub>O6<\/sub>, per litre.<\/p>\n

When Glucose Infusion is required as a diluent for Injections or Infusions of the Pharmacopoeia, Glucose Infusion (50 g per litre) shall be used.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. 11.6 update) Glucose Injection Glucose Intravenous Infusion DEFINITION Glucose Infusion is a sterile solution containing Glucose or Glucose Monohydrate. It is supplied as a ready-to-use solution. The infusion complies with the requirements stated under Parenteral Preparations and with the following requirements. Content of glucose, C6H12O6 95.0 to 105.0% of the stated amount. CHARACTERISTICS…<\/p>\n","protected":false},"author":4,"featured_media":16127,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-16126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=16126"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16126\/revisions"}],"predecessor-version":[{"id":16131,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/16126\/revisions\/16131"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/16127"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=16126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=16126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=16126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}