{"id":15799,"date":"2025-10-18T09:12:49","date_gmt":"2025-10-18T02:12:49","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=15799"},"modified":"2025-10-18T09:12:49","modified_gmt":"2025-10-18T02:12:49","slug":"heavy-kaolin","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/heavy-kaolin\/","title":{"rendered":"Heavy Kaolin"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0503)<\/em><\/p>\n<p><strong>Preparation<\/strong><\/p>\n<p>Kaolin Poultice<\/p>\n<p>When kaolin is prescribed or demanded, Light Kaolin shall be dispensed or supplied, unless it is ascertained that Light Kaolin (Natural) is required.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Purified, natural, hydrated aluminium silicate of variable composition.<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>Fine, white or greyish-white, unctuous powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Practically insoluble in water and in organic solvents.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. To 0.5 g in a metal crucible add 1 g of potassium nitrate R and 3 g of sodium carbonate R and heat until the mixture melts. Allow to cool. To the residue add 20 mL of boiling water R, mix and filter. Wash the residue with 50 mL of water R. To the residue add 1 mL of hydrochloric acid R and 5 mL of water R. Filter. To the filtrate add 1 mL of strong sodium hydroxide solution R and filter. To the filtrate add 3 mL of ammonium chloride solution R. A gelatinous white precipitate is formed.<\/p>\n<p>B. Add 2.0 g in 20 portions to 100 mL of a 10 g\/L solution of sodium laurilsulfate R in a 100 mL graduated cylinder about 30 mm in diameter. Allow 2 min between additions for each portion to settle. Allow to stand for 2 h. The apparent volume of the sediment is not greater than 5 mL.<\/p>\n<p>C. 0.25 g gives the reaction of silicates (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<h3>Solution S<\/h3>\n<p>To 4 g add a mixture of 6 mL of acetic acid R and 34 mL of distilled water R, shake for 1 min and filter.<\/p>\n<h3>Acidity or alkalinity<\/h3>\n<p>To 1.0 g add 20 mL of carbon dioxide-free water R, shake for 2 min and filter. To 10 mL of the filtrate add 0.1 mL of phenolphthalein solution R. The solution is colourless. Not more than 0.25 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.<\/p>\n<h3>Organic impurities<\/h3>\n<p>Heat 0.3 g to redness in a calcination tube. The residue is only slightly more coloured than the original substance.<\/p>\n<h3>Adsorption power<\/h3>\n<p>To 1.0 g in a ground-glass-stoppered test-tube add 10.0 mL of a 3.7 g\/L solution of methylene blue R and shake for 2 min. Allow to settle. Centrifuge and dilute the solution 1 to 100 with water R. The solution is not more intensely coloured than a 0.03 g\/L solution of methylene blue R.<\/p>\n<h3>Swelling power<\/h3>\n<p>Triturate 2 g with 2 mL of water R. The mixture does not flow.<\/p>\n<h3>Substances soluble in dilute hydrochloric acid<\/h3>\n<p>Maximum 1 per cent.<\/p>\n<p>To 5.0 g add 7.5 mL of dilute hydrochloric acid R and 27.5 mL of water R and boil for 5 min. Filter, wash the residue on the filter with water R and dilute the combined filtrate and washings to 50.0 mL with water R. To 10.0 mL of the solution add 1.5 mL of dilute sulfuric acid R, evaporate to dryness on a water-bath and ignite. The residue weighs a maximum of 10 mg.<\/p>\n<h3>Chlorides (2.4.4)<\/h3>\n<p>Maximum 250 ppm.<\/p>\n<p>Dilute 2 mL of solution S to 15 mL with water R.<\/p>\n<h3>Sulfates (2.4.13)<\/h3>\n<p>Maximum 0.1 per cent.<\/p>\n<p>Dilute 1.5 mL of solution S to 15 mL with distilled water R.<\/p>\n<h3>Calcium (2.4.3)<\/h3>\n<p>Maximum 250 ppm.<\/p>\n<p>Dilute 4 mL of solution S to 15 mL with distilled water R.<\/p>\n<h3>Microbial contamination<\/h3>\n<p>TAMC: acceptance criterion 10 CFU\/g (2.6.12).<\/p>\n<p>TYMC: acceptance criterion 10 CFU\/g (2.6.12).<\/p>\n<p>LABELLING<\/p>\n<p>The label states, where applicable, that the substance is suitable for internal use.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0503) Preparation Kaolin Poultice When kaolin is prescribed or demanded, Light Kaolin shall be dispensed or supplied, unless it is ascertained that Light Kaolin (Natural) is required. DEFINITION Purified, natural, hydrated aluminium silicate of variable composition. CHARACTERS Appearance Fine, white or greyish-white, unctuous powder. Solubility Practically insoluble in water and in organic&#8230;<\/p>\n","protected":false},"author":4,"featured_media":15801,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-15799","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=15799"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15799\/revisions"}],"predecessor-version":[{"id":15803,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15799\/revisions\/15803"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/15801"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=15799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=15799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=15799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}