{"id":15400,"date":"2025-10-17T15:44:57","date_gmt":"2025-10-17T08:44:57","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=15400"},"modified":"2025-11-15T15:46:13","modified_gmt":"2025-11-15T08:46:13","slug":"glipizide","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/glipizide\/","title":{"rendered":"Glipizide"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0906)<\/em><\/p>\n<p>C<sub>21<\/sub>H<sub>27<\/sub>N<sub>5<\/sub>O<sub>4<\/sub>S 445.5 29094-61-9<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Inhibition of ATP-dependent potassium channels (sulfonylurea); treatment of diabetes mellitus.<\/p>\n<p><strong>Preparation<\/strong><\/p>\n<p>Glipizide Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>N-[2-[4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl]ethyl]-5-methylpyrazine-2-carboxamide.<\/p>\n<h3>Content<\/h3>\n<p>98.0 per cent to 102.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white, crystalline powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Practically insoluble in water, very slightly soluble in acetone and in methylene chloride, practically insoluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: A.<\/p>\n<p>Second identification: B.<\/p>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: glipizide CRS.<\/p>\n<p>B. Melting point (2.2.14).<\/p>\n<p>Determination A: Determine the melting point of the substance to be examined.<\/p>\n<p>Result A: 203 \u00b0C to 208 \u00b0C.<\/p>\n<p>Determination B: Mix equal parts of the substance to be examined and glipizide CRS and determine the melting point of the mixture.<\/p>\n<p>Result B: The absolute difference between the melting point of the mixture and the value obtained in determination A is not greater than 2 \u00b0C.<\/p>\n<h2>TESTS<\/h2>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29).<\/p>\n<p>Solvent mixture: Mix 40 volumes of acetonitrile R and 60 volumes of water R previously adjusted to pH 3.5 with acetic acid R.<\/p>\n<p>Test solution: Dissolve 20.0 mg of the substance to be examined in 20.0 mL of methanol R using sonication and dilute to 50.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (a): Dilute 1.0 mL of the test solution to 100.0 mL with the solvent mixture. Dilute 1.0 mL of this solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (b): Dissolve 6.0 mg of glipizide impurity A CRS in the solvent mixture and dilute to 100.0 mL with the solvent mixture. Dilute 1.0 mL of the solution to 50.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (c): Dissolve 2 mg of glipizide impurity C CRS in the solvent mixture and dilute to 100 mL with the solvent mixture. Dilute 1 mL of the solution to 100 mL with the solvent mixture.<\/p>\n<p>Reference solution (d): Dissolve 2 mg of glipizide impurity D CRS in the solvent mixture and dilute to 250 mL with the solvent mixture. Dilute 1 mL of the solution to 20 mL with reference solution (b).<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.25 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: base-deactivated end-capped octadecylsilyl silica gel for chromatography R (5 \u03bcm).<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: water for chromatography R adjusted to pH 3.5 with acetic acid R;<\/p>\n<p>\u2014 mobile phase B: acetonitrile for chromatography R;<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">0 &#8211; 5<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">75<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">25<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">5 &#8211; 12<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">75 \u2192 65<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">25 \u2192 35<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">12 &#8211; 20<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">65<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">35<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">20 &#8211; 25<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">65 \u2192 50<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">35 \u2192 50<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">25 &#8211; 30<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">50<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">50<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 1.0 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 225 nm.<\/p>\n<p>Injection: 50 \u03bcL.<\/p>\n<p>Identification of impurities: Use the chromatogram obtained with reference solution (b) to identify the peak due to impurity A; use the chromatogram obtained with reference solution (c) to identify the peak due to impurity C; use the chromatogram obtained with reference solution (d) to identify the peak due to impurity D.<\/p>\n<p>Relative retention: With reference to glipizide (retention time = about 22 min): impurity A = about 0.25; impurity D = about 0.27; impurity C = about 1.2.<\/p>\n<p>System suitability: Reference solution (d):<\/p>\n<p>\u2014 peak-to-valley ratio: minimum 2.0, where Hp = height above the baseline of the peak due to impurity D and Hv = height above the baseline of the lowest point of the curve separating this peak from the peak due to impurity A.<\/p>\n<p>Limits:<\/p>\n<p>\u2014 correction factor: for the calculation of content, multiply the peak area of impurity C by 1.7;<\/p>\n<p>\u2014 impurity A: not more than the area of the corresponding peak in the chromatogram obtained with reference solution (b) (0.3 per cent);<\/p>\n<p>\u2014 impurity C: not more than 1.5 times the area of the principal peak in the chromatogram obtained with reference solution (a) (0.15 per cent);<\/p>\n<p>\u2014 unspecified impurities: for each impurity, not more than the area of the principal peak in the chromatogram obtained with reference solution (a) (0.10 per cent);<\/p>\n<p>\u2014 total: maximum 0.5 per cent;<\/p>\n<p>\u2014 disregard limit: 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (a) (0.05 per cent).<\/p>\n<h3>Impurity B<\/h3>\n<p>Gas chromatography (2.2.28).<\/p>\n<p>Internal standard solution: Dissolve 25.0 mg of decane R in methylene chloride R and dilute to 100.0 mL with the same solvent. Dilute 5.0 mL of the solution to 100.0 mL with methylene chloride R.<\/p>\n<p>Test solution (a): Dissolve 1.000 g of the substance to be examined in 50 mL of a 12 g\/L solution of sodium hydroxide R and shake with 2 quantities, each of 5.0 mL, of methylene chloride R. Use the combined lower layers.<\/p>\n<p>Test solution (b): Dissolve 1.000 g of the substance to be examined in 50 mL of a 12 g\/L solution of sodium hydroxide R and shake with 2 quantities, each of 5.0 mL, of the internal standard solution. Use the combined lower layers.<\/p>\n<p>Reference solution: Dissolve 10.0 mg of cyclohexylamine R (impurity B) in a 17.5 g\/L solution of hydrochloric acid R and dilute to 100.0 mL with the same acid. To 1.0 mL of this solution add 50 mL of a 12 g\/L solution of sodium hydroxide R and shake with 2 quantities, each of 5.0 mL, of the internal standard solution. Use the combined lower layers.<\/p>\n<p>Column:<\/p>\n<p>\u2014 material: fused silica;<\/p>\n<p>\u2014 size: l = 25 m, \u00d8 = 0.32 mm;<\/p>\n<p>\u2014 stationary phase: phenyl(5)methyl(95)polysiloxane R (film thickness 0.5 \u03bcm).<\/p>\n<p>Carrier gas helium for chromatography R.<\/p>\n<p>Flow rate 1.8 mL\/min.<\/p>\n<p>Split ratio 1:11.<\/p>\n<p>Temperature:<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\"><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Temperature<\/strong><\/p>\n<p><strong>(\u00b0C)<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Column<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">\u00a00 &#8211; 4<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">40<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><\/td>\n<td style=\"width: 33.3333%; text-align: center;\">4 &#8211; 20<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">40 \u2192 200<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><\/td>\n<td style=\"width: 33.3333%; text-align: center;\">20 &#8211; 25<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">200<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Injection port<\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><\/td>\n<td style=\"width: 33.3333%; text-align: center;\">250<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Detector<\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><\/td>\n<td style=\"width: 33.3333%; text-align: center;\">270<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Detection: Flame ionisation.<\/p>\n<p>Injection: 1 \u03bcL.<\/p>\n<p>Elution order: Impurity B, decane.<\/p>\n<p>System suitability:<\/p>\n<p>\u2014 resolution: minimum 7 between the peaks due to impurity B and the internal standard in the chromatogram obtained with the reference solution;<\/p>\n<p>\u2014 there is no peak with the same retention time as that of the internal standard in the chromatogram obtained with test solution (a).<\/p>\n<p>Calculate the ratio (R) of the area of the peak due to impurity B to the area of the peak due to the internal standard from the chromatogram obtained with the reference solution; from the chromatogram obtained with test solution (b), calculate the ratio of the area of any peak due to impurity B to the area of the peak due to the internal standard.<\/p>\n<p>Limit:<\/p>\n<p>\u2014 impurity B: not more than R (100 ppm).<\/p>\n<h3>Loss on drying (2.2.32)<\/h3>\n<p>Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105 \u00b0C.<\/p>\n<h3>Sulfated ash (2.4.14)<\/h3>\n<p>Maximum 0.2 per cent, determined on 1.0 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.400 g in 50 mL of dimethylformamide R. Add 0.2 mL of quinaldine red solution R. Titrate with 0.1 M lithium methoxide until the colour changes from red to colourless.<\/p>\n<p>1 mL of 0.1 M lithium methoxide is equivalent to 44.55 mg of C<sub>21<\/sub>H<sub>27<\/sub>N<sub>5<\/sub>O<sub>4<\/sub>S.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) D, E, F, G, H, I, J.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15597\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-224-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-224-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-224-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-224-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-224.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 5-methyl-N-[2-(4-sulfamoylphenyl)ethyl]pyrazine-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15598\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-209-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-209-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-209-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-209-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-209.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. cyclohexanamine (cyclohexylamine),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15599\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-190-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-190-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-190-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-190-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-190.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. ethyl [2-[4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl]ethyl]carbamate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15600\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-151-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-151-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-151-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-151-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-151.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>D. 6-methyl-N-[2-(4-sulfamoylphenyl)ethyl]pyrazine-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15601\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-120-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-120-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-120-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-120-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-120.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. N-[2-[4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl]ethyl]-6-methylpyrazine-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15602\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-99-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-99-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-99-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-99-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-99.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. ethyl [2-(4-sulfamoylphenyl)ethyl]carbamate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15603\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-74-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-74-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-74-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-74-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-74.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. methyl [4-[2-(5-methylpyrazine-2-carboxamido)ethyl]benzene-1-sulfonyl]carbamate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15604\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-52-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-52-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-52-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-52-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-52.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. 4-[2-[(cyclohexylcarbamoyl)amino]ethyl]benzene-1-sulfonamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15605\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-45-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-45-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-45-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-45-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-45.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. N-(cyclohexylcarbamoyl)-4-[2-[(cyclohexylcarbamoyl)amino]ethyl]benzene-1-sulfonamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15606\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-32-300x163.jpg\" alt=\"Glipizide \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-32-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-32-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-32-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-32.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. ethyl [4-[2-(5-methylpyrazine-2-carboxamido)ethyl]benzene-1-sulfonyl]carbamate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0906) C21H27N5O4S 445.5 29094-61-9 Action and use Inhibition of ATP-dependent potassium channels (sulfonylurea); treatment of diabetes mellitus. Preparation Glipizide Tablets DEFINITION N-[2-[4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl]ethyl]-5-methylpyrazine-2-carboxamide. Content 98.0 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline powder. Solubility Practically insoluble in water, very slightly soluble in acetone and in&#8230;<\/p>\n","protected":false},"author":4,"featured_media":15596,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[189],"class_list":["post-15400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances","tag-glipizide"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=15400"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15400\/revisions"}],"predecessor-version":[{"id":15611,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15400\/revisions\/15611"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/15596"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=15400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=15400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=15400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}