{"id":15139,"date":"2025-10-16T14:52:57","date_gmt":"2025-10-16T07:52:57","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=15139"},"modified":"2025-10-16T14:52:57","modified_gmt":"2025-10-16T07:52:57","slug":"fluticasone-furoate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/fluticasone-furoate\/","title":{"rendered":"Fluticasone Furoate"},"content":{"rendered":"<p>(Ph. Eur. monograph 2768)<\/p>\n<p>C<sub>27<\/sub>H<sub>29<\/sub>F<sub>3<\/sub>O<sub>6<\/sub>S 538.6 397864-44-7<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Glucocorticoid.<\/p>\n<h2>DEFINITION<\/h2>\n<p>6\u03b1,9-Difluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl furan-2- carboxylate.<\/p>\n<h3>Content<\/h3>\n<p>98.0 per cent to 102.0 per cent (anhydrous substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Practically insoluble in water, slightly soluble to practically insoluble in anhydrous ethanol, practically insoluble in heptane.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: fluticasone furoate CRS.<\/p>\n<h2>TESTS<\/h2>\n<h3>Related substances<\/h3>\n<p>A. Liquid chromatography (2.2.29). Protect the solutions from light.<\/p>\n<p>Solvent mixture acetonitrile R, water R (50:50 V\/V).<\/p>\n<p>Test solution: Dissolve 25.0 mg of the substance to be examined in 50 mL of acetonitrile R using sonication until complete dissolution, add about 48 mL of water R, mix, allow to equilibrate at room temperature and dilute to 100.0 mL with water R.<\/p>\n<p>Reference solution (a): Dissolve 25.0 mg of fluticasone furoate CRS in 50 mL of acetonitrile R using sonication until complete dissolution, add about 48 mL of water R, mix, allow to equilibrate at room temperature and dilute to 100.0 mL with water R.<\/p>\n<p>Reference solution (b): Dilute 1.0 mL of the test solution to 100.0 mL with the solvent mixture. Dilute 1.0 mL of this solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (c): Dissolve 2.5 mg of fluticasone furoate for peak identification CRS (containing impurities A, B and K) in 5 mL of acetonitrile R using sonication until complete dissolution and dilute to 10 mL with water R.<\/p>\n<p>Reference solution (d): Dissolve 2.5 mg of fluticasone furoate for system suitability CRS (containing impurity F) in 5 mL of acetonitrile R using sonication until complete dissolution and dilute to 10 mL with water R.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.15 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: octylsilyl silica gel for chromatography R (3.5 \u03bcm);<\/p>\n<p>\u2014 temperature: 50 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: methanol R1, acetonitrile for chromatography R, 0.1 per cent V\/V solution of trifluoroacetic acid R (10:30:60 V\/V\/V);<\/p>\n<p>\u2014 mobile phase B: methanol R1, acetonitrile for chromatography R (25:75 V\/V);<\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 106px;\">\n<tbody>\n<tr style=\"height: 43px;\">\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0 &#8211; 2<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">100<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">2 &#8211; 32<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">\u00a0100 \u2192 33<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0 \u2192 67<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 1.5 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 245 nm.<\/p>\n<p>Injection: 10 \u03bcL of the test solution and reference solutions (b), (c) and (d).<\/p>\n<p>Identification of impurities: Use chromatogram A supplied with fluticasone furoate for peak identification CRS and the chromatogram obtained with reference solution (c) to identify the peaks due to impurities A, B and K; use chromatogram A supplied with fluticasone furoate for system suitability CRS and the chromatogram obtained with reference solution (d) to identify the peak due to impurity F.<\/p>\n<p>Relative retention: With reference to fluticasone furoate (retention time = about 15 min): impurity A = about 0.6; impurity B = about 0.8; impurities E, F and G = about 1.1; impurity K = about 1.3.<\/p>\n<p>System suitability: Reference solution (d):<\/p>\n<p>\u2014 resolution: minimum 4.0 between the peaks due to fluticasone furoate and impurity F.<\/p>\n<p>Calculation of percentage contents:<\/p>\n<p>\u2014 correction factors: multiply the peak areas of the following impurities by the corresponding correction factor: impurity B = 1.6; impurity K = 1.7;<\/p>\n<p>\u2014 for each impurity, use the concentration of fluticasone furoate in reference solution (b).<\/p>\n<p>Limits:<\/p>\n<p>\u2014 impurity K: maximum 0.3 per cent;<\/p>\n<p>\u2014 impurities A, B: for each impurity, maximum 0.15 per cent;<\/p>\n<p>\u2014 sum of impurities E, F and G: maximum 0.15 per cent;<\/p>\n<p>\u2014 unspecified impurities: for each impurity, maximum 0.10 per cent;<\/p>\n<p>\u2014 total: maximum 1.0 per cent;<\/p>\n<p>\u2014 reporting threshold: 0.05 per cent.<\/p>\n<p>B. Perform test B only in cases where, in test A, any peak with a relative retention of about 1.1 and\/or 1.16 exceeds the prescribed limits.<\/p>\n<p>Liquid chromatography (2.2.29) as described in test A for related substances with the following modifications.<\/p>\n<p>Column:<\/p>\n<p>\u2014 temperature: 55 \u00b0C.<\/p>\n<p>Mobile phase: Mix 18 volumes of tetrahydrofuran R, 28 volumes of methanol R1 and 54 volumes of water for chromatography R and add 0.05 volumes of trifluoroacetic acid R.<\/p>\n<p>Flow rate: 1.3 mL\/min.<\/p>\n<p>Run time: 3.5 times the retention time of fluticasone furoate.<\/p>\n<p>Identification of impurities: Use chromatogram B supplied with fluticasone furoate for peak identification CRS and thechromatogram obtained with reference solution (c) to identify the peaks due to\u00a0 impurities A, B and K; use chromatogram B supplied with fluticasone furoate for system suitability CRS and the chromatogram obtained with reference solution (d) to<br \/>\nidentify the peak due to impurity F. Relative retention With reference to fluticasone furoate (retention time = about 14 min): impurity F = about 1.1.<\/p>\n<p>System suitability: Reference solution (d):<\/p>\n<p>\u2014 resolution: minimum 2.0 between the peaks due to fluticasone furoate and impurity F.<\/p>\n<p>Calculation of percentage contents:<\/p>\n<p>\u2014 for each impurity, use the concentration of fluticasone furoate in reference solution (b).<\/p>\n<p>Limits:<\/p>\n<p>\u2014 any impurity: for each impurity, maximum 0.10 per cent;<\/p>\n<p>\u2014 reporting threshold: 0.05 per cent; disregard the peaks due to impurities A, B and K.<\/p>\n<h3>Water (2.5.32)<\/h3>\n<p>Maximum 0.2 per cent, determined on 0.100 g using the evaporation technique at 110 \u00b0C.<\/p>\n<h3>Sulfated ash (2.4.14)<\/h3>\n<p>Maximum 0.1 per cent, determined on 1.0 g in a platinum crucible.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29) as described in test A for related substances with the following modification<\/p>\n<p>Injection: Test solution and reference solution (a).<\/p>\n<p>Calculate the percentage content of C<sub>27<\/sub>H<sub>29<\/sub>F<sub>3<\/sub>O<sub>6<\/sub>S taking into account the assigned content of fluticasone furoate CRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>Protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, E, F, G, K.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) H, I, J, L.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15145\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-212-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-212-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-212-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-212-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-212.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 6\u03b1,9-difluoro-17\u03b1-[(furan-2-carbonyl)oxy]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-diene-17\u03b2-carboxylic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15146\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-198-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-198-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-198-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-198-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-198.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. 6\u03b1,9-difluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl acetate (fluticasone propionate impurity C),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15147\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-180-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-180-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-180-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-180-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-180.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. 9-fluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl furan-2-carboxylate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15148\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-145-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-145-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-145-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-145-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-145.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. propan-2-yl 6\u03b1,9-difluoro-17\u03b1-[(furan-2-carbonyl)oxy]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-diene-17\u03b2-carboxylate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15149\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-114-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-114-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-114-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-114-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-114.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. 9-chloro-6\u03b1-fluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-ylfuran-2-carboxylate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15150\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-95-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-95-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-95-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-95-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-95.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. 6\u03b1-chloro-9-fluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl furan-2-carboxylate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15151\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-70-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-70-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-70-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-70-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-70.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. 6\u03b1,9-difluoro-17\u03b2-[(fluoromethoxy)carbonothioyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl furan-2-carboxylate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15152\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-49-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-49-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-49-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-49-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-49.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. 6\u03b1,9-difluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl 5-chlorofuran-2-carboxylate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15153\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-42-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-42-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-42-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-42-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-42.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>K. 6\u03b1,9-difluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl 6\u03b1,9-difluoro-11\u03b2,17\u03b1-dihydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-diene-17\u03b2-carboxylate (fluticasone propionate impurity G),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-15154\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-29-300x163.jpg\" alt=\"Fluticasone Furoate \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-29-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-29-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-29-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-29.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>L. 6\u03b1,9-difluoro-17\u03b1-[(furan-2-carbonyl)oxy]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-diene-17\u03b2-carboxylic 6\u03b1,9-difluoro-11\u03b2,17\u03b1-dihydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b2-carboxylic dithioperoxyanhydride.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 2768) C27H29F3O6S 538.6 397864-44-7 Action and use Glucocorticoid. DEFINITION 6\u03b1,9-Difluoro-17\u03b2-[[(fluoromethyl)sulfanyl]carbonyl]-11\u03b2-hydroxy-16\u03b1-methyl-3-oxoandrosta-1,4-dien-17\u03b1-yl furan-2- carboxylate. Content 98.0 per cent to 102.0 per cent (anhydrous substance). CHARACTERS Appearance White or almost white powder. Solubility Practically insoluble in water, slightly soluble to practically insoluble in anhydrous ethanol, practically insoluble in heptane. IDENTIFICATION Infrared absorption spectrophotometry (2.2.24). Comparison:&#8230;<\/p>\n","protected":false},"author":4,"featured_media":15144,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-15139","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=15139"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15139\/revisions"}],"predecessor-version":[{"id":15162,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/15139\/revisions\/15162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/15144"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=15139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=15139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=15139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}