Action and use<\/strong><\/p>\n General anaesthetic.<\/p>\n (RS)-2-Bromo-2-chloro-1,1,1-trifluoroethane to which 0.01 per cent m\/m of thymol has been added.<\/p>\n Clear, colourless, mobile, heavy, non-flammable liquid.<\/p>\n Slightly soluble in water, miscible with anhydrous ethanol.<\/p>\n First identification: B.<\/p>\n Second identification: A, C.<\/p>\n A. Distillation range (see Tests).<\/p>\n B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n Preparation: Examine the substance in a 0.1 mm cell.<\/p>\n Comparison: Ph. Eur. reference spectrum of halothane.<\/p>\n C. Add 0.1 mL to 2 mL of 2-methyl-2-propanol R in a test-tube. Add 1 mL of copper edetate solution R, 0.5 mL of concentrated ammonia R and a mixture of 0.4 mL of strong hydrogen peroxide solution R and 1.6 mL of water R (solution A). Prepare a blank at the same time (solution B). Place both tubes in a water-bath at 50 \u00b0C for 15 min, cool and add 0.3 mL of glacial acetic acid R. To 1 mL of each of solutions A and B add 0.5 mL of a mixture of equal volumes of freshly prepared alizarin S solution R and zirconyl nitrate solution R. Solution A is yellow and solution B is red.<\/p>\n To 1 mL of each of solutions A and B add 1 mL of buffer solution pH 5.2 R, 1 mL of phenol red solution R diluted 1 to 10 with water R and 0.1 mL of chloramine solution R. Solution A is bluish-violet and solution B is yellow.<\/p>\n To 2 mL of each of solutions A and B add 0.5 mL of a mixture of 25 volumes of sulfuric acid R and 75 volumes of water R, 0.5 mL of acetone R and 0.2 mL of a 50 g\/L solution of potassium bromate R and shake. Warm the tubes in a water-bath at 50 \u00b0C for 2 min, cool and add 0.5 mL of a mixture of equal volumes of nitric acid R and water R and 0.5 mL of silver nitrate solution R2. Solution A is opalescent and a white precipitate is formed after a few minutes; solution B remains clear.<\/p>\n To 20 mL add 20 mL of carbon dioxide-free water R, shake for 3 min and allow to stand. Separate the aqueous layer and add 0.2 mL of bromocresol purple solution R. Not more than 0.1 mL of 0.01 M sodium hydroxide or 0.6 mL of 0.01 M hydrochloric acid is required to change the colour of the indicator.<\/p>\n 1.872 to 1.877.<\/p>\n It distils completely between 49.0 \u00b0C and 51.0 \u00b0C and 95 per cent distills within a range of 1.0 \u00b0C.<\/p>\n Gas chromatography (2.2.28).<\/p>\n Internal standard: trichlorotrifluoroethane CRS.<\/p>\n Test solution (a): The substance to be examined.<\/p>\n Test solution (b): Dilute 1.0 mL of trichlorotrifluoroethane CRS to 20.0 mL with the substance to be examined. Dilute 1.0 mL of the solution to 100.0 mL with the substance to be examined. Dilute 1.0 mL of this solution to 10.0 mL with the substance to be examined.<\/p>\n Column:<\/p>\n \u2014 size: l = 2.75 m, \u00d8 = 5 mm;<\/p>\n \u2014 stationary phase: silanised diatomaceous earth for gas chromatography R (180-250 \u03bcm), the first 1.8 m being impregnated with 30 per cent m\/m of macrogol 400 R and the remainder with 30 per cent m\/m of dinonyl phthalate R;<\/p>\n \u2014 temperature: 50 \u00b0C.<\/p>\n Carrier gas: nitrogen for chromatography R.<\/p>\n Flow rate: 30 mL\/min.<\/p>\n Detection: Flame ionisation.<\/p>\n Injection: 5 \u03bcL.<\/p>\n Limit: Test solution (b):<\/p>\n \u2014 total: not more than the area of the peak due to the internal standard, corrected if necessary for any impurity with the same retention time as the internal standard (0.005 per cent).<\/p>\n Gas chromatography (2.2.28).<\/p>\n Internal standard solution: Dissolve 0.10 g of menthol R in methylene chloride R and dilute to 100.0 mL with the same solvent.<\/p>\n Test solution: To 20.0 mL of the substance to be examined add 5.0 mL of the internal standard solution.<\/p>\n Reference solution: Dissolve 20.0 mg of thymol R in methylene chloride R and dilute to 100.0 mL with the same solvent.<\/p>\n To 20.0 mL of this solution, add 5.0 mL of the internal standard solution.<\/p>\n Column:<\/p>\n \u2014 material: fused silica;<\/p>\n \u2014 size: l = 15 m, \u00d8 = 0.53 mm;<\/p>\n \u2014 stationary phase: methylpolysiloxane R (film thickness 1.5 \u03bcm).<\/p>\n Carrier gas: nitrogen for chromatography R.<\/p>\n Flow rate: 15 mL\/min.<\/p>\n Temperature:<\/p>\n \u2014 column: 150 \u00b0C;<\/p>\n \u2014 injection port: 170 \u00b0C;<\/p>\n \u2014 detector: 200 \u00b0C.<\/p>\n Detection: Flame ionisation.<\/p>\n Injection: 1.0 \u03bcL.<\/p>\n Limit:<\/p>\n \u2014 thymol: 0.75 times to 1.15 times the area of the corresponding peak in the chromatogram obtained with the reference solution (0.008 per cent m\/m to 0.012 per cent m\/m).<\/p>\n To 10 mL add 20 mL of water R and shake for 3 min. To 5 mL of the aqueous layer add 5 mL of water R, 0.05 mL of nitric acid R and 0.2 mL of silver nitrate solution R1. The solution is not more opalescent than a mixture of 5 mL of the aqueous layer and 5 mL of water R.<\/p>\n To 10 mL of the aqueous layer obtained in the test for bromides and chlorides add 1 mL of potassium iodide and starch solution R. No blue colour is produced.<\/p>\n Maximum 20 mg\/L.<\/p>\n Evaporate 50 mL to dryness on a water-bath and dry the residue in an oven at 100-105 \u00b0C for 2 h. The residue weighs a maximum of 1 mg.<\/p>\n In an airtight container, protected from light, at a temperature not exceeding 25 \u00b0C. The choice of material for the container is made taking into account the particular reactivity of halothane with certain metals.<\/p>\n A. (E)-1,1,1,4,4,4-hexafluorobut-2-ene,<\/p>\n B. (EZ)-2-chloro-1,1,1,4,4,4-hexafluorobut-2-ene (cis and trans),<\/p>\n C. (EZ)-2,3-dichloro-1,1,1,4,4,4-hexafluorobut-2-ene (cis and trans),<\/p>\n D. (E)-2-bromo-1,1,1,4,4,4-hexafluorobut-2-ene,<\/p>\n E. 2-chloro-1,1,1-trifluoroethane,<\/p>\n F. 1,1,2-trichloro-1,2,2-trifluoroethane,<\/p>\n G. 1-bromo-1-chloro-2,2-difluoroethene,<\/p>\n H. 2,2-dichloro-1,1,1-trifluoroethane,<\/p>\n I. 1-bromo-1,1-dichloro-2,2,2-trifluoroethane,<\/p>\n J. 1,2-dichloro-1,1-difluoroethane.<\/p>\n","protected":false},"excerpt":{"rendered":" (Ph. Eur. monograph 0393) C2HBrClF3\u00a0 \u00a0 \u00a0 \u00a0197.4\u00a0 \u00a0 \u00a0 \u00a0151-67-7 Action and use General anaesthetic. DEFINITION (RS)-2-Bromo-2-chloro-1,1,1-trifluoroethane to which 0.01 per cent m\/m of thymol has been added. CHARACTERS Appearance Clear, colourless, mobile, heavy, non-flammable liquid. Solubility Slightly soluble in water, miscible with anhydrous ethanol. IDENTIFICATION First identification: B. Second identification: A, C. A….<\/p>\n","protected":false},"author":2,"featured_media":14623,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-14487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/14487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=14487"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/14487\/revisions"}],"predecessor-version":[{"id":14528,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/14487\/revisions\/14528"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/14623"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=14487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=14487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=14487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
Solubility<\/h3>\n
IDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
Acidity or alkalinity<\/h3>\n
Relative density (2.2.5)<\/h4>\n
Distillation range (2.2.11)<\/h4>\n
Volatile related substances<\/h3>\n
Thymol<\/h4>\n
Bromides and chlorides<\/h3>\n
Bromine and chlorine<\/h3>\n
Non-volatile matter<\/h3>\n
STORAGE<\/h2>\n
IMPURITIES<\/h2>\n
![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-A-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-B-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-C-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-D-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-E-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-F-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-G-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-H-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-I-300x163.jpg\")
<\/p>\n![\"Halothane\"](\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Halothane-J-300x163.jpg\")
<\/p>\n