{"id":13833,"date":"2025-10-14T11:27:41","date_gmt":"2025-10-14T04:27:41","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=13833"},"modified":"2025-11-15T15:54:53","modified_gmt":"2025-11-15T08:54:53","slug":"hydrated-manganese-glycerophosphate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/hydrated-manganese-glycerophosphate\/","title":{"rendered":"Hydrated Manganese Glycerophosphate"},"content":{"rendered":"

(Ph. Eur. monograph 2163)<\/p>\n

C3<\/sub>H7<\/sub>MnO6<\/sub>P,xH2<\/sub>O\u00a0 \u00a0 225.0\u00a0 \u00a0 (anhydrous substance)<\/p>\n

DEFINITION<\/h2>\n

Mixture of variable proportions of hydrated manganese(II) (2RS)-2,3-dihydroxypropyl phosphate and
\nhydrated manganese(II) 2-hydroxy-1-(hydroxymethyl)ethyl phosphate.<\/p>\n

Content<\/h3>\n

97.0 per cent to 102.0 per cent (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or pale pink, hygroscopic powder.<\/p>\n

Solubility<\/h3>\n

Practically insoluble in water and in ethanol (96 per cent). It is freely soluble in dilute mineral acids.<\/p>\n

IDENTIFICATION<\/h2>\n

A. Mix 1 g with 1 g of potassium hydrogen sulfate R in a test tube fitted with a delivery tube. Heat strongly
\nand direct the white vapour towards a piece of filter paper impregnated with a freshly prepared 10 g\/L
\nsolution of sodium nitroprusside R. The filter paper develops a blue colour in contact with piperidine R.<\/p>\n

B. Disperse 50 mg in 5 mL of water R. Add 0.5 mL of ammonium sulfide solution R. A pale pink precipitate
\nis formed that dissolves on the addition of 1 mL of acetic acid R.<\/p>\n

C. Ignite 0.1 g in a crucible. Take up the residue with 5 mL of nitric acid R and heat on a water-bath for
\n1 min. Filter. The filtrate gives reaction (b) of phosphates (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 5.0 g in 20 mL of dilute hydrochloric acid R. Filter if necessary. Add dilute ammonia R1 until a
\nprecipitate is formed. Dissolve the precipitate by adding the minimum quantity needed of dilute hydrochloric
\nacid R and dilute to 100 mL with distilled water R.<\/p>\n

Glycerol and ethanol (96 per cent)-soluble substances<\/h3>\n

Maximum 1.0 per cent.<\/p>\n

Shake 1.00 g with 25 mL of ethanol (96 per cent) R for 1 min. Filter. Evaporate the filtrate to dryness on a
\nwater-bath and dry the residue at 70 \u00b0C for 1 h. The residue weighs a maximum of 10 mg.<\/p>\n

Chlorides (2.4.4)<\/h3>\n

Maximum 0.15 per cent.<\/p>\n

Dissolve 0.22 g in a mixture of 1 mL of nitric acid R and 10 mL of water R and dilute to 100 mL with water R.<\/p>\n

Phosphates (2.4.11)<\/h3>\n

Maximum 0.3 per cent.<\/p>\n

Dilute 1.0 mL of solution S to 100.0 mL with water R. To 10 mL of this solution add 140 mL of water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n

Maximum 0.2 per cent.<\/p>\n

Dilute 5 mL of solution S to 50 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n

Maximum 50 ppm.<\/p>\n

Dilute 4 mL of solution S to 10 mL with water R.<\/p>\n

Loss on drying (2.2.32)<\/h4>\n

Maximum 12.0 per cent, determined on 1.000 g by drying in an oven at 105 \u00b0C for 4 h.<\/p>\n

ASSAY<\/h3>\n

To 0.200 g add 1.5 mL of 1 M hydrochloric acid, 50 mL of water R, 10 mg of ascorbic acid R and 20 mL of
\nammonium chloride buffer solution pH 10.0 R. Stir until dissolution. Immediately add 0.3 mL of a 2 g\/L
\nsolution of mordant black 11 R in triethanolamine R and titrate with 0.1 M sodium edetate until the colour
\nchanges from violet to pure blue.<\/p>\n

1 mL of 0.1 M sodium edetate is equivalent to 22.50 mg of C3<\/sub>H7<\/sub>MnO6<\/sub>P.<\/p>\n

STORAGE<\/h2>\n

In an airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 2163) C3H7MnO6P,xH2O\u00a0 \u00a0 225.0\u00a0 \u00a0 (anhydrous substance) DEFINITION Mixture of variable proportions of hydrated manganese(II) (2RS)-2,3-dihydroxypropyl phosphate and hydrated manganese(II) 2-hydroxy-1-(hydroxymethyl)ethyl phosphate. Content 97.0 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or pale pink, hygroscopic powder. Solubility Practically insoluble in water and in ethanol (96 per cent). It…<\/p>\n","protected":false},"author":3,"featured_media":13861,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-13833","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=13833"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13833\/revisions"}],"predecessor-version":[{"id":13917,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13833\/revisions\/13917"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/13861"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=13833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=13833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=13833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}