{"id":13102,"date":"2025-10-13T09:22:00","date_gmt":"2025-10-13T02:22:00","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=13102"},"modified":"2025-10-13T09:22:00","modified_gmt":"2025-10-13T02:22:00","slug":"ferrous-sulfate-heptahydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/ferrous-sulfate-heptahydrate\/","title":{"rendered":"Ferrous Sulfate Heptahydrate"},"content":{"rendered":"

Ferrous Sulphate Heptahydrate<\/p>\n

(Ph. Eur. monograph 0083)<\/p>\n

FeSO_{4<\/sub>,7H_{2<\/sub>O\u00a0 \u00a0 \u00a0 \u00a0278.0\u00a0 \u00a0 \u00a0 \u00a07782-63-0<\/p>\n}}

Action and use<\/strong><\/p>\n

Treatment of iron-deficiency anaemia.<\/p>\n

Preparation<\/strong><\/p>\n

Paediatric Ferrous Sulfate Oral Solution<\/p>\n

DEFINITION<\/h2>\n
Content<\/h3>\n
98.0 per cent to 105.0 per cent.<\/p>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
Light green, crystalline powder or bluish-green crystals, efflorescent in air.<\/p>\n
Solubility<\/h3>\n
Freely soluble in water, very soluble in boiling water, practically insoluble in ethanol (96 per cent).<\/p>\n
Ferrous sulfate heptahydrate is oxidised in moist air, becoming brown.<\/p>\n
IDENTIFICATION<\/h2>\n
A. It gives the reactions of sulfates (2.3.1).<\/p>\n
B. It gives reaction (a) of iron (2.3.1).<\/p>\n
C. It complies with the limits of the assay.<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 4.0 g in a 5 per cent V\/V solution of lead-free nitric acid R and dilute to 100.0 mL with the same solution.<\/p>\n
pH (2.2.3)<\/h4>\n
3.0 to 4.0.<\/p>\n
Dissolve 1.0 g in carbon dioxide-free water R and dilute to 20 mL with the same solvent.<\/p>\n
Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 5 mL of solution S to 10 mL with water R and add 5 mL of dilute nitric acid R. Prepare the standard with a mixture of 2 mL of water R, 5 mL of dilute nitric acid R and 8 mL of chloride standard solution (5 ppm Cl) R. Use 0.15 mL of silver
\nnitrate solution R2 in this test.<\/p>\n
Elemental impurities<\/h3>\n
Any method that fulfils the requirements of general chapter 2.4.20. Determination of elemental impurities may be used.<\/p>\n\n\n\n\n\n\n\n
Element <\/strong><\/td>\n Maximum content (ppm)<\/strong><\/td>\n<\/tr>\n
Chromium<\/td>\n 50<\/td>\n<\/tr>\n
Cobalt<\/td>\n 25<\/td>\n<\/tr>\n
Copper<\/td>\n 50<\/td>\n<\/tr>\n
Nickel<\/td>\n 50<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Ferric ions<\/h3>\n
Maximum 0.3 per cent.<\/p>\n
In a ground-glass-stoppered flask, dissolve 5.00 g in a mixture of 10 mL of hydrochloric acid R and 100 mL of carbon dioxide-free water R. Add 3 g of potassium iodide R, close the flask and allow to stand in the dark for 5 min. Titrate the liberated iodine with 0.1 M sodium thiosulfate, using 0.5 mL of starch solution R, added towards the end of the titration, as indicator. Carry out a blank test in the same conditions. Not more than 2.7 mL of 0.1 M sodium thiosulfate is used, taking
\ninto account the blank titration.<\/p>\n
Manganese<\/h3>\n
Maximum 0.1 per cent.<\/p>\n
Atomic absorption spectrometry (2.2.23, Method II).<\/p>\n
Test solution: Dilute 1.0 mL of solution S to 20.0 mL with a 5 per cent V\/V solution of lead-free nitric acid R.<\/p>\n
Reference solutions: Prepare the reference solutions using manganese standard solution (1000 ppm Mn) R, diluting with a 5 per cent V\/V solution of lead-free nitric acid R.<\/p>\n
Source: Manganese hollow-cathode lamp using a transmission band preferably of 1 nm.<\/p>\n
Wavelength: 279.5 nm.<\/p>\n
Atomisation device: Air-acetylene flame.<\/p>\n
Zinc<\/h4>\n
Maximum 50 ppm.<\/p>\n
Atomic absorption spectrometry (2.2.23, Method II).<\/p>\n
Test solution: Solution S.<\/p>\n
Reference solutions: Prepare the reference solutions using zinc standard solution (100 ppm Zn) R, diluting with a 5 per cent V\/V solution of lead-free nitric acid R.
\nSource Zinc hollow-cathode lamp using a transmission band preferably of 1 nm.<\/p>\n
Wavelength: 213.9 nm.<\/p>\n
Atomisation device: Air-acetylene flame.<\/p>\n
ASSAY<\/h2>\n
Dissolve 2.5 g of sodium hydrogen carbonate R in a mixture of 150 mL of water R and 10 mL of sulfuric acid R. When the effervescence ceases add to the solution 0.500 g of the substance to be examined and dissolve with gentle swirling. Add
\n0.1 mL of ferroin R and titrate with 0.1 M ammonium and cerium nitrate until the red colour disappears.<\/p>\n
1 mL of 0.1 M ammonium and cerium nitrate is equivalent to 27.80 mg of FeSO_{4<\/sub>,7H_{2<\/sub>O.<\/p>\n}}
STORAGE<\/h2>\n
In an airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ferrous Sulphate Heptahydrate (Ph. Eur. monograph 0083) FeSO4,7H2O\u00a0 \u00a0 \u00a0 \u00a0278.0\u00a0 \u00a0 \u00a0 \u00a07782-63-0 Action and use Treatment of iron-deficiency anaemia. Preparation Paediatric Ferrous Sulfate Oral Solution DEFINITION Content 98.0 per cent to 105.0 per cent. CHARACTERS Appearance Light green, crystalline powder or bluish-green crystals, efflorescent in air. Solubility Freely soluble in water, very soluble…<\/p>\n","protected":false},"author":2,"featured_media":13109,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-13102","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-volumes-1-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=13102"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13102\/revisions"}],"predecessor-version":[{"id":13111,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13102\/revisions\/13111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/13109"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=13102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=13102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=13102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Element <\/strong><\/td>\n	Maximum content (ppm)<\/strong><\/td>\n<\/tr>\n
Chromium<\/td>\n	50<\/td>\n<\/tr>\n
Cobalt<\/td>\n	25<\/td>\n<\/tr>\n
Copper<\/td>\n	50<\/td>\n<\/tr>\n
Nickel<\/td>\n	50<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Ferric ions<\/h3>\n Maximum 0.3 per cent.<\/p>\n In a ground-glass-stoppered flask, dissolve 5.00 g in a mixture of 10 mL of hydrochloric acid R and 100 mL of carbon dioxide-free water R. Add 3 g of potassium iodide R, close the flask and allow to stand in the dark for 5 min. Titrate the liberated iodine with 0.1 M sodium thiosulfate, using 0.5 mL of starch solution R, added towards the end of the titration, as indicator. Carry out a blank test in the same conditions. Not more than 2.7 mL of 0.1 M sodium thiosulfate is used, taking \ninto account the blank titration.<\/p>\n Manganese<\/h3>\n Maximum 0.1 per cent.<\/p>\n Atomic absorption spectrometry (2.2.23, Method II).<\/p>\n Test solution: Dilute 1.0 mL of solution S to 20.0 mL with a 5 per cent V\/V solution of lead-free nitric acid R.<\/p>\n Reference solutions: Prepare the reference solutions using manganese standard solution (1000 ppm Mn) R, diluting with a 5 per cent V\/V solution of lead-free nitric acid R.<\/p>\n Source: Manganese hollow-cathode lamp using a transmission band preferably of 1 nm.<\/p>\n Wavelength: 279.5 nm.<\/p>\n Atomisation device: Air-acetylene flame.<\/p>\n Zinc<\/h4>\n Maximum 50 ppm.<\/p>\n Atomic absorption spectrometry (2.2.23, Method II).<\/p>\n Test solution: Solution S.<\/p>\n Reference solutions: Prepare the reference solutions using zinc standard solution (100 ppm Zn) R, diluting with a 5 per cent V\/V solution of lead-free nitric acid R. \nSource Zinc hollow-cathode lamp using a transmission band preferably of 1 nm.<\/p>\n Wavelength: 213.9 nm.<\/p>\n Atomisation device: Air-acetylene flame.<\/p>\n ASSAY<\/h2>\n Dissolve 2.5 g of sodium hydrogen carbonate R in a mixture of 150 mL of water R and 10 mL of sulfuric acid R. When the effervescence ceases add to the solution 0.500 g of the substance to be examined and dissolve with gentle swirling. Add \n0.1 mL of ferroin R and titrate with 0.1 M ammonium and cerium nitrate until the red colour disappears.<\/p>\n 1 mL of 0.1 M ammonium and cerium nitrate is equivalent to 27.80 mg of FeSO_{4<\/sub>,7H_{2<\/sub>O.<\/p>\n}} STORAGE<\/h2>\n In an airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":" Ferrous Sulphate Heptahydrate (Ph. Eur. monograph 0083) FeSO4,7H2O\u00a0 \u00a0 \u00a0 \u00a0278.0\u00a0 \u00a0 \u00a0 \u00a07782-63-0 Action and use Treatment of iron-deficiency anaemia. Preparation Paediatric Ferrous Sulfate Oral Solution DEFINITION Content 98.0 per cent to 105.0 per cent. CHARACTERS Appearance Light green, crystalline powder or bluish-green crystals, efflorescent in air. Solubility Freely soluble in water, very soluble…<\/p>\n","protected":false},"author":2,"featured_media":13109,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-13102","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-volumes-1-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=13102"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13102\/revisions"}],"predecessor-version":[{"id":13111,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/13102\/revisions\/13111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/13109"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=13102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=13102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=13102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Content<\/h3>\n98.0 per cent to 105.0 per cent.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nLight green, crystalline powder or bluish-green crystals, efflorescent in air.<\/p>\n

Solubility<\/h3>\nFreely soluble in water, very soluble in boiling water, practically insoluble in ethanol (96 per cent).<\/p>\nFerrous sulfate heptahydrate is oxidised in moist air, becoming brown.<\/p>\n

IDENTIFICATION<\/h2>\nA. It gives the reactions of sulfates (2.3.1).<\/p>\nB. It gives reaction (a) of iron (2.3.1).<\/p>\nC. It complies with the limits of the assay.<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 4.0 g in a 5 per cent V\/V solution of lead-free nitric acid R and dilute to 100.0 mL with the same solution.<\/p>\n

pH (2.2.3)<\/h4>\n3.0 to 4.0.<\/p>\nDissolve 1.0 g in carbon dioxide-free water R and dilute to 20 mL with the same solvent.<\/p>\n

Content<\/h3>\n
98.0 per cent to 105.0 per cent.<\/p>\n

Appearance<\/h3>\n
Light green, crystalline powder or bluish-green crystals, efflorescent in air.<\/p>\n

Solubility<\/h3>\n
Freely soluble in water, very soluble in boiling water, practically insoluble in ethanol (96 per cent).<\/p>\n
Ferrous sulfate heptahydrate is oxidised in moist air, becoming brown.<\/p>\n

IDENTIFICATION<\/h2>\n
A. It gives the reactions of sulfates (2.3.1).<\/p>\n
B. It gives reaction (a) of iron (2.3.1).<\/p>\n
C. It complies with the limits of the assay.<\/p>\n

Solution S<\/h3>\n
Dissolve 4.0 g in a 5 per cent V\/V solution of lead-free nitric acid R and dilute to 100.0 mL with the same solution.<\/p>\n

pH (2.2.3)<\/h4>\n
3.0 to 4.0.<\/p>\n
Dissolve 1.0 g in carbon dioxide-free water R and dilute to 20 mL with the same solvent.<\/p>\n