{"id":12969,"date":"2025-10-13T09:09:36","date_gmt":"2025-10-13T02:09:36","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=12969"},"modified":"2025-11-15T15:36:56","modified_gmt":"2025-11-15T08:36:56","slug":"ferric-chloride-hexahydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/ferric-chloride-hexahydrate\/","title":{"rendered":"Ferric Chloride Hexahydrate"},"content":{"rendered":"

(Ph. Eur. monograph 1515)<\/p>\n

FeCl3<\/sub>,6H2<\/sub>O\u00a0 \u00a0 \u00a0 \u00a0270.3\u00a0 \u00a0 \u00a0 \u00a010025-77-1<\/p>\n

Preparation<\/strong><\/p>\n

Ferric Chloride Injection<\/p>\n

DEFINITION<\/h2>\n

Content<\/h3>\n

98.0 per cent to 102.0 per cent.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

Crystalline mass or orange-yellow or brownish-yellow crystals, very hygroscopic.<\/p>\n

Solubility<\/h3>\n

Very soluble in water and in ethanol (96 per cent), freely soluble in glycerol.<\/p>\n

IDENTIFICATION<\/h2>\n

A. It gives reaction (a) of chlorides (2.3.1).<\/p>\n

B. It gives reaction (c) of iron (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 10 g in distilled water R and dilute to 100 mL with the same solvent.<\/p>\n

Acidity<\/h3>\n

In a suitable polyethylene container, dissolve 3.0 g of potassium fluoride R in 15 mL of water R. Titrate with 0.1 M sodium hydroxide using 0.1 mL of phenolphthalein solution R as indicator until a pink colour is obtained. Add 10 mL of solution S and allow to stand for 3 h. Filter and use 12.5 mL of the filtrate. Not more than 0.30 mL of 0.1 M sodium hydroxide is
\nrequired to change the colour of the indicator to pink.<\/p>\n

Free chlorine<\/h3>\n

Heat 5 mL of solution S. The vapour does not turn starch iodide paper R blue.<\/p>\n

Sulfates (2.4.13)<\/h3>\n

Maximum 100 ppm.<\/p>\n

Heat 15 mL of solution S on a water-bath and add 5 mL of strong sodium hydroxide solution R. Allow to cool and filter. Neutralise the filtrate to blue litmus paper R using hydrochloric acid R1 and evaporate to 15 mL.<\/p>\n

Ferrous ions<\/h3>\n

Maximum 50 ppm.<\/p>\n

To 10 mL of solution S, add 1 mL of water R, and 0.05 mL of potassium ferricyanide solution R followed by 4 mL of phosphoric acid R. After 10 min, any blue colour in the solution is not more intense than that in a standard prepared at the same time and in the same manner using 10 mL of water R and 1 mL of a freshly prepared 0.250 g\/L solution of ferrous sulfate R.<\/p>\n

ASSAY<\/h2>\n

In a conical flask with a ground-glass stopper, dissolve 0.200 g in 20 mL of water R. Add 10 mL of dilute hydrochloric acid R and 2 g of potassium iodide R. Allow the stoppered flask to stand for 1 h protected from light. Titrate with 0.1 M sodium thiosulfate, adding 5 mL of starch solution R towards the end of the titration.<\/p>\n

1 mL of 0.1 M sodium thiosulfate is equivalent to 27.03 mg of FeCl3<\/sub>,6H2<\/sub>O.<\/p>\n

STORAGE<\/h2>\n

In an airtight container, protected from light.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 1515) FeCl3,6H2O\u00a0 \u00a0 \u00a0 \u00a0270.3\u00a0 \u00a0 \u00a0 \u00a010025-77-1 Preparation Ferric Chloride Injection DEFINITION Content 98.0 per cent to 102.0 per cent. CHARACTERS Appearance Crystalline mass or orange-yellow or brownish-yellow crystals, very hygroscopic. Solubility Very soluble in water and in ethanol (96 per cent), freely soluble in glycerol. IDENTIFICATION A. It gives reaction…<\/p>\n","protected":false},"author":2,"featured_media":13097,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-12969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=12969"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12969\/revisions"}],"predecessor-version":[{"id":13099,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12969\/revisions\/13099"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/13097"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=12969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=12969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=12969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}