{"id":12953,"date":"2025-10-11T17:12:09","date_gmt":"2025-10-11T10:12:09","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=12953"},"modified":"2025-10-13T13:37:38","modified_gmt":"2025-10-13T06:37:38","slug":"glacial-acetic-acid","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/glacial-acetic-acid\/","title":{"rendered":"Glacial Acetic Acid"},"content":{"rendered":"

(Ph. Eur. monograph 0590)<\/p>\n

C_{2<\/sub>H_{4<\/sub>O_{2<\/sub>\u00a0 60.1 64-19-7<\/p>\n}}}

DEFINITION<\/h2>\n

Content<\/h3>\n
99.0 per cent m\/m to 100.5 per cent m\/m.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n
Crystalline mass or clear, colourless, volatile liquid.<\/p>\n

Solubility<\/h3>\n
Miscible with water, with ethanol (96 per cent) and with methylene chloride.<\/p>\n

IDENTIFICATION<\/h2>\n
A. A 100 g\/L solution is strongly acid (2.2.4).<\/p>\n
B. To 0.03 mL add 3 mL of water R and neutralise with dilute sodium hydroxide solution R. The solution gives reaction (b) of acetates (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n
Dilute 20 mL to 100 mL with distilled water R.<\/p>\n

Appearance<\/h3>\n
The substance to be examined is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Freezing point (2.2.18)<\/h3>\n
Minimum 14.8 \u00b0C.<\/p>\n

Reducing substances<\/h3>\n
Dilute 2.0 mL to 10.0 mL with water R. Add 0.1 mL of 0.02 M potassium permanganate. Heat on a water-bath for 1 min, the colour remains pink.<\/p>\n

Chlorides (2.4.4)<\/h4>\n
Maximum 25 mg\/L.<\/p>\n
Dilute 10 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h4>\n
Maximum 50 mg\/L, determined on solution S.<\/p>\n

Iron (2.4.9)<\/h4>\n
Maximum 5 ppm.<\/p>\n
Dissolve the residue obtained in the test for residue on evaporation by heating with 2 quantities, each of 15 mL, of water R and dilute to 50.0 mL with water R. Dilute 5.0 mL of the solution to 10.0 mL with water R.<\/p>\n

Residue on evaporation<\/h4>\n
Maximum 0.01 per cent.<\/p>\n
Evaporate 20 g to dryness on a water-bath and dry at 100-105 \u00b0C. The residue weighs a maximum of 2.0 mg.<\/p>\n

ASSAY<\/h2>\n
Weigh accurately a conical flask with a ground-glass stopper containing 25 mL of water R. Add 1.0 mL of the substance to be examined and weigh again accurately. Add 0.5 mL of phenolphthalein solution R and titrate with 1 M sodium hydroxide.<\/p>\n
1 mL of 1 M sodium hydroxide is equivalent to 60.1 mg of C_{2<\/sub>H_{4<\/sub>O_{2<\/sub>.<\/p>\n}}}

STORAGE<\/h2>\n
In an airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":"
(Ph. Eur. monograph 0590) C2H4O2\u00a0 60.1 64-19-7 DEFINITION Content 99.0 per cent m\/m to 100.5 per cent m\/m. CHARACTERS Appearance Crystalline mass or clear, colourless, volatile liquid. Solubility Miscible with water, with ethanol (96 per cent) and with methylene chloride. IDENTIFICATION A. A 100 g\/L solution is strongly acid (2.2.4). B. To 0.03 mL add…<\/p>\n","protected":false},"author":3,"featured_media":12957,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-12953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=12953"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12953\/revisions"}],"predecessor-version":[{"id":12959,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12953\/revisions\/12959"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/12957"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=12953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=12953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=12953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

DEFINITION<\/h2>\n

Content<\/h3>\n99.0 per cent m\/m to 100.5 per cent m\/m.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nCrystalline mass or clear, colourless, volatile liquid.<\/p>\n

Solubility<\/h3>\nMiscible with water, with ethanol (96 per cent) and with methylene chloride.<\/p>\n

IDENTIFICATION<\/h2>\nA. A 100 g\/L solution is strongly acid (2.2.4).<\/p>\nB. To 0.03 mL add 3 mL of water R and neutralise with dilute sodium hydroxide solution R. The solution gives reaction (b) of acetates (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDilute 20 mL to 100 mL with distilled water R.<\/p>\n

Appearance<\/h3>\nThe substance to be examined is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Freezing point (2.2.18)<\/h3>\nMinimum 14.8 \u00b0C.<\/p>\n

Reducing substances<\/h3>\nDilute 2.0 mL to 10.0 mL with water R. Add 0.1 mL of 0.02 M potassium permanganate. Heat on a water-bath for 1 min, the colour remains pink.<\/p>\n

Chlorides (2.4.4)<\/h4>\nMaximum 25 mg\/L.<\/p>\nDilute 10 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h4>\nMaximum 50 mg\/L, determined on solution S.<\/p>\n

Iron (2.4.9)<\/h4>\nMaximum 5 ppm.<\/p>\nDissolve the residue obtained in the test for residue on evaporation by heating with 2 quantities, each of 15 mL, of water R and dilute to 50.0 mL with water R. Dilute 5.0 mL of the solution to 10.0 mL with water R.<\/p>\n

Residue on evaporation<\/h4>\nMaximum 0.01 per cent.<\/p>\nEvaporate 20 g to dryness on a water-bath and dry at 100-105 \u00b0C. The residue weighs a maximum of 2.0 mg.<\/p>\n