(Ph. Eur. monograph 0310)<\/p>\n
Action and use<\/strong><\/p>\n Excipient.<\/p>\n Polysaccharides from various species of Rhodophyceae mainly belonging to the genus Gelidium. It is prepared by treating the algae with boiling water; the extract is filtered whilst hot, concentrated and dried.<\/p>\n Powder or crumpled strips 2-5 mm wide or sometimes flakes, colourless or pale yellow, translucent, somewhat tough and difficult to break, becoming more brittle on drying.<\/p>\n Mucilaginous taste.<\/p>\n A. Examine under a microscope. When mounted in 0.005 M iodine, the strips or flakes are partly stained brownish-violet. Magnified 100 times, they show the following diagnostic characters: numerous minute, colourless, ovoid or rounded grains on an amorphous background; occasional brown, round or ovoid spores with a reticulated surface, measuring up to 60 \u03bcm, may be present. Reduce to a powder, if necessary. The powder is yellowish-white. Examine under a microscope using 0.005 M iodine. The powder presents angular fragments with numerous grains similar to those seen in the strips and flakes; some of the fragments are stained brownish-violet.<\/p>\n B. Dissolve 0.1 g with heating in 50 mL of water R. Cool. To 1 mL of the mucilage carefully add 3 mL of water R so as to form 2 separate layers. Add 0.1 mL of 0.05 M iodine. A dark brownish-violet colour appears at the interface. Mix. The liquid becomes pale yellow.<\/p>\n C. Heat 5 mL of the mucilage prepared for identification test B on a water-bath with 0.5 mL of hydrochloric acid R for 30 min. Add 1 mL of barium chloride solution R1. A white turbidity develops within 30 min.<\/p>\n D. Heat 0.5 g with 50 mL of water R on a water-bath until dissolved. Only a few fragments remain insoluble. During cooling, the solution gels between 35 \u00b0C and 30 \u00b0C. Heat the gel thus obtained on a water-bath; it does not liquefy below 80 \u00b0C.<\/p>\n Minimum 10 and within 10 per cent of the value stated on the label, determined on the powdered herbal drug (355) (2.9.12).<\/p>\n Maximum 1.0 per cent.<\/p>\n To 5.00 g of the powdered herbal drug (355) (2.9.12) add 100 mL of water R and 14 mL of dilute hydrochloric acid R. Boil gently for 15 min with frequent stirring. Filter the hot liquid through a tared, sintered-glass filter (160) (2.1.2), rinse the filter with hot water R and dry at 100-105 \u00b0C. The residue weighs a maximum of 50 mg.<\/p>\n To 1.00 g add 100 mL of water R and heat on a water-bath until dissolved. Allow to cool to 50 \u00b0C. To 5 mL of this solution add 5 mL of picric acid solution R. No turbidity appears within 10 min.<\/p>\n Maximum 20.0 per cent, determined on 1.000 g of the powdered herbal drug (355) (2.9.12) by drying in an oven at 105 \u00b0C.<\/p>\n Maximum 5.0 per cent.<\/p>\n TAMC: acceptance criterion 10 CFU\/g (2.6.12).<\/p>\n TYMC: acceptance criterion 10 CFU\/g (2.6.12).<\/p>\n Absence of Escherichia coli (2.6.13).<\/p>\n Absence of Salmonella (2.6.13).<\/p>\n The label states the swelling index.<\/p>\n","protected":false},"excerpt":{"rendered":" (Ph. Eur. monograph 0310) Action and use Excipient. DEFINITION Polysaccharides from various species of Rhodophyceae mainly belonging to the genus Gelidium. It is prepared by treating the algae with boiling water; the extract is filtered whilst hot, concentrated and dried. CHARACTERS Appearance Powder or crumpled strips 2-5 mm wide or sometimes flakes, colourless or pale…<\/p>\n","protected":false},"author":2,"featured_media":1877,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-1286","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=1286"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1286\/revisions"}],"predecessor-version":[{"id":5140,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1286\/revisions\/5140"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/1877"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=1286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=1286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=1286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
IDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
Swelling index (2.8.4)<\/h4>\n
Insoluble matter<\/h3>\n
Gelatin<\/h4>\n
Loss on drying (2.2.32)<\/h4>\n
Total ash (2.4.16)<\/h4>\n
Microbial contamination<\/h3>\n
LABELLING<\/h2>\n