{"id":12749,"date":"2025-10-11T14:23:38","date_gmt":"2025-10-11T07:23:38","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=12749"},"modified":"2025-10-11T14:23:38","modified_gmt":"2025-10-11T07:23:38","slug":"dimercaprol","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/dimercaprol\/","title":{"rendered":"Dimercaprol"},"content":{"rendered":"

(Ph. Eur. monograph 0389)<\/p>\n

C3<\/sub>H8<\/sub>OS2<\/sub> 124.2 59-52-9<\/p>\n

Action and use<\/strong><\/p>\n

Chelating agent for use in heavy metal poisoning.<\/p>\n

Preparation<\/strong><\/p>\n

Dimercaprol Injection<\/p>\n

When B.A.L. is prescribed or demanded, Dimercaprol shall be dispensed or supplied.<\/p>\n

DEFINITION<\/h2>\n

(2RS)-2,3-Disulfanylpropan-1-ol.<\/p>\n

Content<\/h3>\n

98.5 per cent to 101.5 per cent.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

Clear, colourless or slightly yellow liquid.<\/p>\n

Solubility<\/h3>\n

Soluble in water and in arachis oil, miscible with ethanol (96 per cent) and with benzyl benzoate.<\/p>\n

IDENTIFICATION<\/h2>\n

A. Dissolve 0.05 mL in 2 mL of water R. Add 1 mL of 0.05 M iodine. The colour of the iodine is discharged immediately.<\/p>\n

B. Dissolve 0.1 mL in 5 mL of water R and add 2 mL of copper sulfate solution R. A bluish-black precipitate is formed which quickly becomes dark grey.
\nC. In a ground-glass-stoppered tube, suspend 0.6 g of sodium bismuthate R, previously heated to 200 \u00b0C for 2 h, in a mixture of 2.8 mL of dilute phosphoric acid R and 6 mL of water R. Add 0.2 mL of the substance to be examined, mix and allow to stand for 10 min with frequent shaking. To 1 mL of the supernatant add 5 mL of a 4 g\/L solution of chromotropic acid, sodium salt R in sulfuric acid R and mix. Heat in a water-bath for 15 min. A violet-red colour develops.<\/p>\n

TESTS<\/h2>\n

Appearance<\/h3>\n

It is clear (2.2.1) and not more intensely coloured than reference solution B6 or BY6 (2.2.2, Method II).<\/p>\n

Acidity or alkalinity<\/h3>\n

Dissolve 0.2 g in carbon dioxide-free water R and dilute to 10 mL with the same solvent. Add 0.25 mL of bromocresol green solution R and 0.3 mL of 0.01 M hydrochloric acid.<\/p>\n

The solution is yellow. Not more than 0.5 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to blue.<\/p>\n

Refractive index (2.2.6)<\/h3>\n

1.568 to 1.574.<\/p>\n

Halides<\/h3>\n

To 2.0 g add 25 mL of alcoholic potassium hydroxide solution R and boil under a reflux condenser for 2 h. Eliminate the ethanol by evaporation in a stream of hot air. Add 20 mL of water R and cool. Add 40 mL of water R and 10 mL of strong hydrogen peroxide solution R, boil gently for 10 min, cool and filter rapidly. Add 10 mL of dilute nitric acid R and 5.0 mL of 0.1 M silver nitrate. Using 2 mL of ferric ammonium sulfate solution R2 as indicator, titrate with 0.1 M ammonium thiocyanate until a reddish-yellow colour is obtained. Carry out a blank titration. The difference between the titration volumes is not greater than 1.0 mL.<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.100 g in 40 mL of methanol R. Add 20 mL of 0.1 M hydrochloric acid and 50.0 mL of 0.05 M iodine. Allow to stand for 10 min and titrate with 0.1 M sodium thiosulfate. Carry out a blank titration.<\/p>\n

1 mL of 0.05 M iodine is equivalent to 6.21 mg of C3<\/sub>H8<\/sub>OS2<\/sub>.<\/p>\n

STORAGE<\/h2>\n

In a well-filled, airtight container, protected from light, at a temperature of 2 \u00b0C to 8 \u00b0C.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 0389) C3H8OS2 124.2 59-52-9 Action and use Chelating agent for use in heavy metal poisoning. Preparation Dimercaprol Injection When B.A.L. is prescribed or demanded, Dimercaprol shall be dispensed or supplied. DEFINITION (2RS)-2,3-Disulfanylpropan-1-ol. Content 98.5 per cent to 101.5 per cent. CHARACTERS Appearance Clear, colourless or slightly yellow liquid. Solubility Soluble in water…<\/p>\n","protected":false},"author":4,"featured_media":12755,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-12749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=12749"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12749\/revisions"}],"predecessor-version":[{"id":12757,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/12749\/revisions\/12757"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/12755"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=12749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=12749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=12749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}