{"id":1241,"date":"2025-09-18T15:05:35","date_gmt":"2025-09-18T08:05:35","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=1241"},"modified":"2025-10-01T16:20:36","modified_gmt":"2025-10-01T09:20:36","slug":"aciclovir","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/aciclovir\/","title":{"rendered":"Aciclovir"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0968)<\/em><\/p>\n<p>C<sub>8<\/sub>H<sub>11<\/sub>N<sub>5<\/sub>O<sub>3<\/sub>\u00a0 \u00a0225.2\u00a0 \u00a059277-89-3<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Purine nucleoside analogue; antiviral (herpesviruses).<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Aciclovir Cream<\/p>\n<p>Aciclovir Eye Ointment<\/p>\n<p>Aciclovir Infusion<\/p>\n<p>Aciclovir Oral Suspension<\/p>\n<p>Aciclovir Tablets<\/p>\n<p>Aciclovir Dispersible Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one.<\/p>\n<h3>Content<\/h3>\n<p>98.5 per cent to 101.0 per cent (anhydrous substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white, crystalline powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in heptane. It dissolves in dilute solutions of mineral acids and alkali hydroxides.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison aciclovir CRS.<\/p>\n<h2>TESTS<\/h2>\n<h3>Appearance of solution<\/h3>\n<p>The solution is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).<\/p>\n<p>Dissolve 0.25 g in a 4 g\/L solution of sodium hydroxide R and dilute to 25 mL with the same solvent.<\/p>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29). <em>Prepare the solutions immediately before use.<\/em><\/p>\n<p><em>Solvent mixture:<\/em>\u00a0dimethyl sulfoxide R, water R (20:80 V\/V).<\/p>\n<p><em>Phosphate buffer solution pH 2.5<\/em>\u00a0 Dissolve 3.48 g of dipotassium hydrogen phosphate R in 1000 mL of water for chromatography R and adjust to pH 2.5 with phosphoric acid R.<\/p>\n<p><em>Phosphate buffer solution pH<\/em>\u00a0 3.1 Dissolve 3.48 g of dipotassium hydrogen phosphate R in 1000 mL of water for chromatography R and adjust to pH 3.1 with phosphoric acid R.<\/p>\n<p><em>Test solution:<\/em>\u00a0Dissolve 25 mg of the substance to be examined in 5.0 mL of dimethyl sulfoxide R and dilute to 25.0 mL with water R.<\/p>\n<p><em>Reference solution (a):<\/em>\u00a0Dissolve 5 mg of aciclovir for system suitability A CRS (containing impurities B, J, K, N, O and P) in 1 mL of dimethyl sulfoxide R and dilute to 5 mL with water R.<\/p>\n<p><em>Reference solution (b):<\/em>\u00a0Dilute 1.0 mL of the test solution to 100.0 mL with the solvent mixture. Dilute 1.0 mL of this solution to 10.0 mL with the solvent mixture.<\/p>\n<p><em>Reference solution (c):<\/em>\u00a0Dissolve the contents of a vial of aciclovir for impurity C identification CRS in 200 \u03bcL of dimethyl sulfoxide R and dilute to 1 mL with water R.<\/p>\n<p><em>Reference solution (d):<\/em>\u00a0Dissolve the contents of a vial of aciclovir for impurity G identification CRS in 1 mL of reference solution (a).<\/p>\n<p><em>Column:<\/em><\/p>\n<p><em>\u2014 size:<\/em> l = 0.25 m, \u00d8 = 4.6 mm;<\/p>\n<p><em>\u2014 stationary phase:<\/em> end-capped octadecylsilyl silica gel for chromatography R (5 \u03bcm).<\/p>\n<p><em>Mobile phase:<\/em><\/p>\n<p><em>\u2014 mobile phase A:<\/em> acetonitrile R, phosphate buffer solution pH 3.1 (1:99 V\/V);<\/p>\n<p><em>\u2014 mobile phase B:<\/em> acetonitrile R, phosphate buffer solution pH 2.5 (50:50 V\/V);<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">0 &#8211; 5<\/p>\n<p>5 &#8211; 27<\/p>\n<p>27 &#8211; 40<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">100<\/p>\n<p>100 \u2192 80<\/p>\n<p>80<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">0<\/p>\n<p>0 \u2192 20<\/p>\n<p>20<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>Flow rate:<\/em>\u00a01.0 mL\/min.<\/p>\n<p><em>Detection:<\/em>\u00a0Spectrophotometer at 254 nm.<\/p>\n<p><em>Injection:<\/em>\u00a010 \u03bcL of the test solution and reference solutions (b), (c) and (d).<\/p>\n<p><em>Identification of impurities:<\/em>\u00a0Use the chromatogram supplied with aciclovir for impurity C identification CRS and the chromatogram obtained with reference solution (c) to identify the peak due to impurity C ; use the chromatograms supplied with aciclovir for system suitability A CRS and aciclovir for impurity G identification CRS and the chromatogram obtained with reference solution (d) to identify the peaks due to impurities B, G, J, K, N, O and P.<\/p>\n<p><em>Relative retention:<\/em>\u00a0With reference to aciclovir (retention time = about 13 min): impurity B = about 0.4; impurity P = about 0.7; impurity C = about 0.9; impurity N = about 1.37; impurities O and Q = about 1.42; impurity J = about 1.62; impurities K and R = about 2.5; impurity G = about 2.6.<\/p>\n<p><em>System suitability:<\/em><\/p>\n<p><em>\u2014 resolution:<\/em> minimum 1.5 between the peaks due to impurity C and aciclovir in the chromatogram obtained with reference solution (c); minimum 1.5 between the peaks due to impurities K and G in the chromatogram obtained with reference solution (d).<\/p>\n<p><em>Limits:<\/em><\/p>\n<p><em>\u2014 correction factor:<\/em> for the calculation of content, multiply the peak area of impurity C by 2.2;<\/p>\n<p><em>\u2014 impurity B:<\/em> not more than 7 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.7 per cent)<\/p>\n<p><em>\u2014 impurity J:<\/em> not more than twice the area of the principal peak in the chromatogram obtained with reference solution (b) (0.2 per cent);<\/p>\n<p><em>\u2014 sum of impurities K and R:<\/em> not more than 1.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.15 per cent);<\/p>\n<p><em>\u2014 sum of impurities O and Q:<\/em> not more than 1.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) ( 0.15 per cent);<\/p>\n<p><em>\u2014 impurities C, N, P:<\/em> for each impurity, not more than 1.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.15 per cent);<\/p>\n<p><em>\u2014 unspecified impurities:<\/em> for each impurity, not more than 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.05 per cent);<\/p>\n<p><em>\u2014 total:<\/em> not more than 10 times the area of the principal peak in the chromatogram obtained with reference solution (b) (1.0 per cent);<\/p>\n<p><em>\u2014 disregard limit:<\/em> 0.3 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.03 per cent).<\/p>\n<h3>Water (2.5.12)<\/h3>\n<p>Maximum 6.0 per cent, determined on 0.500 g.<\/p>\n<h3>Sulfated ash (2.4.14)<\/h3>\n<p>Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.150 g in 60 mL of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically (2.2.20). Carry out a blank titration.<\/p>\n<p>1 mL of 0.1 M perchloric acid is equivalent to 22.52 mg of C<sub>8<\/sub>H<sub>11<\/sub>N<sub>5<\/sub>O<sub>3<\/sub>.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities B, C, J, K, N, O, P, Q, R.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) A, F, G, I, L, M.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7224\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-174-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-174-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-174-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-174-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-174.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7225\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-157-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-157-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-157-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-157-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-157.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. 2-amino-1,7-dihydro-6H-purin-6-one (guanine),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7226\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-137-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-137-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-137-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-137-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-137.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. 2-amino-7-[(2-hydroxyethoxy)methyl]-1,7-dihydro-6H-purin-6-one,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7227\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-120-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-120-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-120-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-120-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-120.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. N-[9-[(2-hydroxyethoxy)methyl]-6-oxo-6,9-dihydro-1H-purin-2-yl]acetamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7228\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-102-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-102-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-102-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-102-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-102.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. 2-[(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7229\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-78-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-78-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-78-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-78-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-78.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. 2-amino-7-[[2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethoxy]methyl]-1,7-dihydro-6H-purin-6-one,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7230\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-61-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-61-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-61-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-61-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-61.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. 9,9\u2032-[ethane-1,2-diylbis(oxymethylene)]bis(2-amino-1,9-dihydro-6H-purin-6-one),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7231\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-51-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-51-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-51-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-51-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-51.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>K. 2,2\u2032-(methylenediazanediyl)bis[9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one],<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7232\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/11-41-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/11-41-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/11-41-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/11-41-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/11-41.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>L.N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide (N ,9-diacetylguanine),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7233\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/12-35-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/12-35-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/12-35-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/12-35-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/12-35.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>M. 2-[(2-acetamido-6-oxo-1,6-dihydro-7H-purin-7-yl)methoxy]ethyl acetate,<\/p>\n<p>N. unknown structure,<\/p>\n<p>O. unknown structure,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7234\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/13-30-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/13-30-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/13-30-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/13-30-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/13-30.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>P. 2-amino-9-(2-hydroxyethyl)-1,9-dihydro-6H-purin-6-one, 2<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7235\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/14-22-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/14-22-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/14-22-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/14-22-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/14-22.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Q. mixture of 2-amino-9-[[2-(hydroxyethoxy) methoxy]methyl]-1,9-dihydro-6H-purin-6-one and 2-amino-9-[[2-(hydroxymethoxy)ethoxy]methyl]-1,9-dihydro-6H-purin-6-<br \/>\none,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7236\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/15-14-300x163.jpg\" alt=\"Acyclovir\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/15-14-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/15-14-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/15-14-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/15-14.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>R. 9,9\u2032-[methylenebis(oxyethane-2,1-diyloxymethylene)]bis(2-amino-1,9-dihydro-6H-purin-6-one).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0968) C8H11N5O3\u00a0 \u00a0225.2\u00a0 \u00a059277-89-3 Action and use Purine nucleoside analogue; antiviral (herpesviruses). Preparations Aciclovir Cream Aciclovir Eye Ointment Aciclovir Infusion Aciclovir Oral Suspension Aciclovir Tablets Aciclovir Dispersible Tablets DEFINITION 2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one. Content 98.5 per cent to 101.0 per cent (anhydrous substance). CHARACTERS Appearance White or almost white, crystalline powder. Solubility Slightly soluble in&#8230;<\/p>\n","protected":false},"author":4,"featured_media":1295,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-1241","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=1241"}],"version-history":[{"count":11,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1241\/revisions"}],"predecessor-version":[{"id":7245,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1241\/revisions\/7245"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/1295"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=1241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=1241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=1241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}