{"id":11822,"date":"2025-10-10T09:46:06","date_gmt":"2025-10-10T02:46:06","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=11822"},"modified":"2025-10-10T09:46:06","modified_gmt":"2025-10-10T02:46:06","slug":"econazole","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/econazole\/","title":{"rendered":"Econazole"},"content":{"rendered":"<p>(Ph. Eur. monograph 2049)<\/p>\n<p>C<sub>18<\/sub>H<sub>15<\/sub>Cl<sub>3<\/sub>N<sub>2<\/sub>O\u00a0 \u00a0 \u00a0 381.7\u00a0 \u00a0 \u00a0 \u00a027220-47-9<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Antifungal.<\/p>\n<h2>DEFINITION<\/h2>\n<p>1-[(2RS)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole.<\/p>\n<h3>Content<\/h3>\n<p>99.0 per cent to 101.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Practically insoluble in water, very soluble in ethanol (96 per cent) and in methylene chloride.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Melting point (2.2.14): 88 \u00b0C to 92 \u00b0C.<\/p>\n<p>B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: econazole CRS.<\/p>\n<h2>TESTS<\/h2>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29).<\/p>\n<p>Test solution: Dissolve 0.100 g of the substance to be examined in methanol R and dilute to 10.0 mL with the same<br \/>\nsolvent.<\/p>\n<p>Reference solution (a): Dissolve 10 mg of econazole for system suitability CRS (containing impurities A, B and C) in methanol R and dilute to 1.0 mL with the same solvent.<\/p>\n<p>Reference solution (b): Dilute 1.0 mL of the test solution to 20.0 mL with methanol R. Dilute 1.0 mL of this solution to 25.0 mL with methanol R.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.10 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: base-deactivated octadecylsilyl silica gel for chromatography R (3 \u03bcm);<\/p>\n<p>\u2014 temperature: 35 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: methanol R, 0.77 g\/L solution of ammonium acetate R (20:80 V\/V);<\/p>\n<p>\u2014 mobile phase B: methanol R, acetonitrile R (40:60 V\/V);<\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 74px;\">\n<tbody>\n<tr style=\"height: 43px;\">\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Time<\/strong><br \/>\n<strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase A<\/strong><br \/>\n<strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 43px; text-align: center;\"><strong>Mobile phase B<\/strong><br \/>\n<strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">0 &#8211; 25<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">60 \u2192 10<\/td>\n<td style=\"width: 33.3333%; height: 21px; text-align: center;\">40 \u2192 90<\/td>\n<\/tr>\n<tr style=\"height: 10px;\">\n<td style=\"width: 33.3333%; height: 10px; text-align: center;\">25 &#8211; 27<\/td>\n<td style=\"width: 33.3333%; height: 10px; text-align: center;\">10<\/td>\n<td style=\"width: 33.3333%; height: 10px; text-align: center;\">90<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 1.5 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 225 nm.<\/p>\n<p>Injection: 10 \u03bcL.<\/p>\n<p>Identification of impurities: Use the chromatogram supplied with econazole for system suitability CRS and the<br \/>\nchromatogram obtained with reference solution (a) to identify the peaks due to impurities A, B and C.<\/p>\n<p>Relative retention: With reference to econazole (retention time = about 15 min): impurity A = about 0.2;<br \/>\nimpurity B = about 0.6; impurity C = about 1.1.<\/p>\n<p>System suitability: Reference solution (a):<\/p>\n<p>\u2014 peak-to-valley ratio: minimum 1.5, where Hp = height above the baseline of the peak due to impurity C and H<sub>v<\/sub> = height above the baseline of the lowest point of the curve separating this peak from the peak due to econazole.<\/p>\n<p>Limits:<\/p>\n<p>\u2014 correction factor: for the calculation of content, multiply the peak area of impurity A by 1.4;<\/p>\n<p>\u2014 impurities A, B, C: for each impurity, not more than the area of the principal peak in the chromatogram obtained with reference solution (b) (0.2 per cent);<\/p>\n<p>\u2014 unspecified impurities: for each impurity, not more than 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.10 per cent);<\/p>\n<p>\u2014 total: not more than 1.5 times the area of the principal peak in the chromatogram obtained with reference<br \/>\nsolution (b) (0.3 per cent);<\/p>\n<p>\u2014 disregard limit: 0.25 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.05 per cent).<\/p>\n<h4>Loss on drying (2.2.32)<\/h4>\n<p>Maximum 0.5 per cent, determined on 1.000 g by drying in vacuo at 60 \u00b0C for 4 h.<\/p>\n<h4>Sulfated ash (2.4.14)<\/h4>\n<p>Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.300 g in 75 mL of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically (2.2.20). Carry out a blank titration.<\/p>\n<p>1 mL of 0.1 M perchloric acid is equivalent to 38.17 mg of C<sub>18<\/sub>H<sub>15<\/sub>Cl<sub>3<\/sub>N<sub>2<\/sub>O.<\/p>\n<h2>STORAGE<\/h2>\n<p>Protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11844\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-A-300x163.jpg\" alt=\"Econazole\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-A-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-A-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-A-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-A.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. (1RS)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11845\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-B-300x163.jpg\" alt=\"Econazole\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-B-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-B-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-B-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-B.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. (2RS)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethanamine,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11846\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-C-300x163.jpg\" alt=\"Econazole\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-C-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-C-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-C-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/Econazole-C.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. 1-(4-chlorobenzyl)-3-[(2RS)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]imidazolium.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 2049) C18H15Cl3N2O\u00a0 \u00a0 \u00a0 381.7\u00a0 \u00a0 \u00a0 \u00a027220-47-9 Action and use Antifungal. DEFINITION 1-[(2RS)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole. Content 99.0 per cent to 101.0 per cent (dried substance). CHARACTERS Appearance White or almost white powder. Solubility Practically insoluble in water, very soluble in ethanol (96 per cent) and in methylene chloride. IDENTIFICATION A. Melting point (2.2.14):&#8230;<\/p>\n","protected":false},"author":2,"featured_media":11847,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-11822","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/11822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=11822"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/11822\/revisions"}],"predecessor-version":[{"id":11850,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/11822\/revisions\/11850"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/11847"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=11822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=11822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=11822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}