{"id":11213,"date":"2025-10-09T11:05:07","date_gmt":"2025-10-09T04:05:07","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=11213"},"modified":"2025-10-09T11:05:07","modified_gmt":"2025-10-09T04:05:07","slug":"ethyl-acetate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/ethyl-acetate\/","title":{"rendered":"Ethyl Acetate"},"content":{"rendered":"

(Ph. Eur. monograph 0899)<\/p>\n

C4<\/sub>H8<\/sub>O2<\/sub>\u00a0 \u00a088.1 141-78-6<\/p>\n

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

DEFINITION<\/h2>\n

Ethyl ethanoate.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

Clear, colourless, volatile liquid.<\/p>\n

Solubility<\/h3>\n

Soluble in water, miscible with acetone, with ethanol (96 per cent) and with methylene chloride.<\/p>\n

IDENTIFICATION<\/h2>\n

First identification: B.<\/p>\n

Second identification: A, C, D.<\/p>\n

A. Boiling point (2.2.12): 76 \u00b0C to 78 \u00b0C.<\/p>\n

B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n

Comparison Ph. Eur. reference spectrum of ethyl acetate.<\/p>\n

C. It gives the reaction of acetyl (2.3.1).<\/p>\n

D. It gives the reaction of esters (2.3.1).<\/p>\n

TESTS<\/h2>\n

Appearance of solution<\/h3>\n

The solution is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Mix 1 mL of the substance to be examined and 15 mL of water R.<\/p>\n

Acidity<\/h3>\n

To 10 mL of ethanol (96 per cent) R add 0.1 mL of phenolphthalein solution R and 0.01 M sodium hydroxide until the colour changes to pink. Add 5.5 mL of the substance to be examined and 0.25 mL of 0.02 M sodium hydroxide. The solution remains pink for not less than 15 s.<\/p>\n

Relative density (2.2.5)<\/h3>\n

0.898 to 0.902.<\/p>\n

Refractive index (2.2.6)<\/h3>\n

1.370 to 1.373.<\/p>\n

Reaction with sulfuric acid<\/h3>\n

Carefully add 2 mL to 10 mL of sulfuric acid R. After 15 min, the interface between the 2 liquids is not coloured.<\/p>\n

Related substances<\/h3>\n

Gas chromatography (2.2.28).<\/p>\n

Test solution The substance to be examined.<\/p>\n

Column:<\/p>\n

\u2014 material: glass;<\/p>\n

\u2014 size: l = 2 m, \u00d8 = 2 mm;<\/p>\n

\u2014 stationary phase: ethylvinylbenzene-divinylbenzene copolymer R (136-173 \u03bcm).<\/p>\n

Carrier gas nitrogen for chromatography R.<\/p>\n

Flow rate 30 mL\/min.<\/p>\n

Temperature:<\/p>\n\n\n\n\n\n\n\n
<\/td>\nTime
\n(min)<\/td>\n		Temperature
\n(\u00b0C)<\/td>\n<\/tr>\n
Column<\/td>\n0 – 18.8<\/td>\n\u00a090 \u2192 240<\/td>\n<\/tr>\n
<\/td>\n18.8 – 26.8<\/td>\n240<\/td>\n<\/tr>\n
Injection port<\/td>\n<\/td>\n240<\/td>\n<\/tr>\n
Detector<\/td>\n<\/td>\n240<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Limit:<\/p>\n

\u2014 total: not more than 0.2 per cent of the area of the principal peak.<\/p>\n

Residue on evaporation<\/p>\n

Maximum 30 ppm.<\/p>\n

Evaporate 100.0 g to dryness on a water-bath and dry in an oven at 100-105 \u00b0C. The residue weighs not more than 3 mg.<\/p>\n

Water (2.5.12)<\/h4>\n

Maximum 0.1 per cent, determined on 10.0 mL.<\/p>\n

STORAGE<\/h2>\n

Protected from light, at a temperature not exceeding 30 \u00b0C.<\/p>\n

IMPURITIES<\/h2>\n

\"Ethyl<\/p>\n

A. methyl ethanoate (methyl acetate),<\/p>\n

\"Ethyl<\/p>\n

B. ethanol,<\/p>\n

\"Ethyl<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 0899) C4H8O2\u00a0 \u00a088.1 141-78-6 Action and use Excipient. DEFINITION Ethyl ethanoate. CHARACTERS Appearance Clear, colourless, volatile liquid. Solubility Soluble in water, miscible with acetone, with ethanol (96 per cent) and with methylene chloride. IDENTIFICATION First identification: B. Second identification: A, C, D. A. Boiling point (2.2.12): 76 \u00b0C to 78 \u00b0C. B….<\/p>\n","protected":false},"author":3,"featured_media":11223,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-11213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/11213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=11213"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/11213\/revisions"}],"predecessor-version":[{"id":11226,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/11213\/revisions\/11226"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/11223"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=11213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=11213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=11213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}