{"id":1104,"date":"2025-09-18T10:15:20","date_gmt":"2025-09-18T03:15:20","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=1104"},"modified":"2025-10-01T15:56:37","modified_gmt":"2025-10-01T08:56:37","slug":"acetone","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/acetone\/","title":{"rendered":"Acetone"},"content":{"rendered":"

(Ph. Eur. monograph 0872)<\/p>\n

C_{3<\/sub>H_{6<\/sub>O 58.08 67-64-1<\/p>\n}}

DEFINITION<\/h2>\n
Propanone.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n
Volatile, clear, colourless liquid.<\/p>\n

Solubility<\/h3>\n
Miscible with water and with ethanol (96 per cent).<\/p>\n
The vapour is flammable.<\/p>\n

IDENTIFICATION<\/h2>\n
A. Relative density (see Tests).<\/p>\n
B. To 1 mL, add 3 mL of dilute sodium hydroxide solution R and 0.3 mL of a 25 g\/L solution of sodium nitroprusside R. An intense red colour is produced which becomes violet with the addition of 3.5 mL of acetic acid R.<\/p>\n
C. To 10 mL of a 0.1 per cent V\/V solution of the substance to be examined in ethanol (50 per cent V\/V) R, add 1 mL of a 10 g\/L solution of nitrobenzaldehyde R in ethanol (50 per cent V\/V) R and 0.5 mL of strong sodium hydroxide solution R. Allow to stand for about 2 min and acidify with acetic acid R. A greenish-blue colour is produced.<\/p>\n

TESTS<\/h2>\n

Appearance of solution<\/h3>\n
To 10 mL add 10 mL of water R. The solution is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Acidity or alkalinity<\/h3>\n
To 5 mL add 5 mL of carbon dioxide-free water R, 0.15 mL of phenolphthalein solution R and 0.5 mL of 0.01 M sodium hydroxide. The solution is pink. Add 0.7 mL of 0.01 M hydrochloric acid and 0.05 mL of methyl red solution R. The solution is red or orange.<\/p>\n

Relative density (2.2.5)<\/h4>\n
0.790 to 0.793.<\/p>\n

Reducing substances<\/h3>\n
To 30 mL add 0.1 mL of 0.02 M potassium permanganate and allow to stand in the dark for 2 h. The mixture is not completely decolourised.<\/p>\n

Related substances<\/h3>\n
Gas chromatography (2.2.28).<\/p>\n
Test solution: The substance to be examined.<\/p>\n
Reference solution (a): To 0.5 mL of methanol R add 0.5 mL of 2-propanol R and dilute to 100.0 mL with the test solution.Dilute 1.0 mL of this solution to 10.0 mL with the test solution.<\/p>\n
Reference solution (b): Dilute 100 \u03bcL of benzene R to 100.0 mL with the test solution. Dilute 0.20 mL of this solution to 100.0 mL with the test solution.<\/p>\n
Column:<\/p>\n
\u2014 material: fused silica,<\/p>\n
\u2014 size: l = 50 m, \u00d8 = 0.3 mm,<\/p>\n
\u2014 stationary phase: macrogol 20 000 R (film thickness 1 \u03bcm).<\/p>\n
Carrier gas helium for chromatography R.<\/p>\n
Linear velocity: 21 cm\/s.<\/p>\n
Split ratio: 1:50.<\/p>\n
Temperature:<\/p>\n\n\n\n\n\n\n
<\/td>\n Time
\n(min)<\/td>\n Temperature
\n(\u00b0C)<\/td>\n<\/tr>\n
Column<\/td>\n 0 – 11<\/p>\n
11-20<\/td>\n
\u00a045 \u2192 100<\/p>\n
100<\/td>\n<\/tr>\n
Injection port<\/td>\n <\/td>\n 150<\/td>\n<\/tr>\n
Detector<\/td>\n <\/td>\n \u00a0250<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Detection: Flame ionisation.<\/p>\n
Injection: 1 \u03bcL.<\/p>\n
Retention time: Impurity C = about 7.5 min.<\/p>\n
System suitability:<\/p>\n
\u2014 resolution: minimum 5.0 between the peak due to impurity A (2 peak) and the peak due to impurity B (3 peak) in the chromatogram obtained with reference solution (a);<\/p>\n
\u2014 signal-to-noise ratio: minimum 5 for the peak due to impurity C in the chromatogram obtained with reference solution (b).<\/p>\n
Limits:<\/p>\n
\u2014 impurities A, B: for each impurity, not more than the difference between the areas of the corresponding peaks in the chromatogram obtained with reference solution (a) and the areas of the corresponding peaks in the chromatogram obtained with the test solution (0.05 per cent V\/V),<\/p>\n
\u2014 impurity C: not more than the difference between the area of the peak due to impurity C in the chromatogram
\nobtained with reference solution (b) and the area of the corresponding peak in the chromatogram obtained with the test solution (2 ppm V\/V),<\/p>\n
\u2014 any other impurity: for each impurity, not more than the difference between the area of the peak due to impurity A in the chromatogram obtained with reference solution (a) and the area of the corresponding peak in the chromatogram obtained with the test solution (0.05 per cent V\/V).<\/p>\n
Matter insoluble in water<\/h3>\n
Dilute 1.0 mL to 20 mL with water R. The solution is clear (2.2.1).<\/p>\n
Residue on evaporation<\/h3>\n
Maximum 50 ppm.<\/p>\n
Evaporate 20.0 g to dryness on a water-bath and dry at 100-105 \u00b0C. The residue weighs a maximum of 1 mg.<\/p>\n
Water (2.5.12)<\/h4>\n
Maximum 3 g\/L, determined on 10.0 mL.<\/p>\n
STORAGE<\/h2>\n
Protected from light.<\/p>\n
IMPURITIES<\/h2>\n
Specified impurities A, B, C.<\/p>\n
$\"Acetone-1\"$ <\/p>\n
A. methanol,<\/p>\n
$\"Acetone-2\"$ <\/p>\n
B. propan-2-ol (isopropanol),<\/p>\n
$\"Acetone-3\"$ <\/p>\n
C. benzene.<\/p>\n","protected":false},"excerpt":{"rendered":"
(Ph. Eur. monograph 0872) C3H6O 58.08 67-64-1 DEFINITION Propanone. CHARACTERS Appearance Volatile, clear, colourless liquid. Solubility Miscible with water and with ethanol (96 per cent). The vapour is flammable. IDENTIFICATION A. Relative density (see Tests). B. To 1 mL, add 3 mL of dilute sodium hydroxide solution R and 0.3 mL of a 25 g\/L…<\/p>\n","protected":false},"author":3,"featured_media":1111,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-1104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=1104"}],"version-history":[{"count":6,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1104\/revisions"}],"predecessor-version":[{"id":6745,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1104\/revisions\/6745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/1111"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=1104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=1104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=1104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

<\/td>\n	Time \n(min)<\/td>\n	Temperature \n(\u00b0C)<\/td>\n<\/tr>\n
Column<\/td>\n	0 – 11<\/p>\n 11-20<\/td>\n	\u00a045 \u2192 100<\/p>\n 100<\/td>\n<\/tr>\n
Injection port<\/td>\n	<\/td>\n	150<\/td>\n<\/tr>\n
Detector<\/td>\n	<\/td>\n	\u00a0250<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Detection: Flame ionisation.<\/p>\n Injection: 1 \u03bcL.<\/p>\n Retention time: Impurity C = about 7.5 min.<\/p>\n System suitability:<\/p>\n \u2014 resolution: minimum 5.0 between the peak due to impurity A (2 peak) and the peak due to impurity B (3 peak) in the chromatogram obtained with reference solution (a);<\/p>\n \u2014 signal-to-noise ratio: minimum 5 for the peak due to impurity C in the chromatogram obtained with reference solution (b).<\/p>\n Limits:<\/p>\n \u2014 impurities A, B: for each impurity, not more than the difference between the areas of the corresponding peaks in the chromatogram obtained with reference solution (a) and the areas of the corresponding peaks in the chromatogram obtained with the test solution (0.05 per cent V\/V),<\/p>\n \u2014 impurity C: not more than the difference between the area of the peak due to impurity C in the chromatogram \nobtained with reference solution (b) and the area of the corresponding peak in the chromatogram obtained with the test solution (2 ppm V\/V),<\/p>\n \u2014 any other impurity: for each impurity, not more than the difference between the area of the peak due to impurity A in the chromatogram obtained with reference solution (a) and the area of the corresponding peak in the chromatogram obtained with the test solution (0.05 per cent V\/V).<\/p>\n Matter insoluble in water<\/h3>\n Dilute 1.0 mL to 20 mL with water R. The solution is clear (2.2.1).<\/p>\n Residue on evaporation<\/h3>\n Maximum 50 ppm.<\/p>\n Evaporate 20.0 g to dryness on a water-bath and dry at 100-105 \u00b0C. The residue weighs a maximum of 1 mg.<\/p>\n Water (2.5.12)<\/h4>\n Maximum 3 g\/L, determined on 10.0 mL.<\/p>\n STORAGE<\/h2>\n Protected from light.<\/p>\n IMPURITIES<\/h2>\n Specified impurities A, B, C.<\/p>\n $\"Acetone-1\"$ <\/p>\n A. methanol,<\/p>\n $\"Acetone-2\"$ <\/p>\n B. propan-2-ol (isopropanol),<\/p>\n $\"Acetone-3\"$ <\/p>\n C. benzene.<\/p>\n","protected":false},"excerpt":{"rendered":" (Ph. Eur. monograph 0872) C3H6O 58.08 67-64-1 DEFINITION Propanone. CHARACTERS Appearance Volatile, clear, colourless liquid. Solubility Miscible with water and with ethanol (96 per cent). The vapour is flammable. IDENTIFICATION A. Relative density (see Tests). B. To 1 mL, add 3 mL of dilute sodium hydroxide solution R and 0.3 mL of a 25 g\/L…<\/p>\n","protected":false},"author":3,"featured_media":1111,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-1104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=1104"}],"version-history":[{"count":6,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1104\/revisions"}],"predecessor-version":[{"id":6745,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/1104\/revisions\/6745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/1111"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=1104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=1104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=1104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

DEFINITION<\/h2>\nPropanone.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nVolatile, clear, colourless liquid.<\/p>\n

Solubility<\/h3>\nMiscible with water and with ethanol (96 per cent).<\/p>\nThe vapour is flammable.<\/p>\n

TESTS<\/h2>\n

Appearance of solution<\/h3>\nTo 10 mL add 10 mL of water R. The solution is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Acidity or alkalinity<\/h3>\nTo 5 mL add 5 mL of carbon dioxide-free water R, 0.15 mL of phenolphthalein solution R and 0.5 mL of 0.01 M sodium hydroxide. The solution is pink. Add 0.7 mL of 0.01 M hydrochloric acid and 0.05 mL of methyl red solution R. The solution is red or orange.<\/p>\n

Relative density (2.2.5)<\/h4>\n0.790 to 0.793.<\/p>\n

Reducing substances<\/h3>\nTo 30 mL add 0.1 mL of 0.02 M potassium permanganate and allow to stand in the dark for 2 h. The mixture is not completely decolourised.<\/p>\n

Matter insoluble in water<\/h3>\nDilute 1.0 mL to 20 mL with water R. The solution is clear (2.2.1).<\/p>\n

Residue on evaporation<\/h3>\nMaximum 50 ppm.<\/p>\nEvaporate 20.0 g to dryness on a water-bath and dry at 100-105 \u00b0C. The residue weighs a maximum of 1 mg.<\/p>\n

Water (2.5.12)<\/h4>\nMaximum 3 g\/L, determined on 10.0 mL.<\/p>\n

STORAGE<\/h2>\nProtected from light.<\/p>\n

DEFINITION<\/h2>\n
Propanone.<\/p>\n

Appearance<\/h3>\n
Volatile, clear, colourless liquid.<\/p>\n

Solubility<\/h3>\n
Miscible with water and with ethanol (96 per cent).<\/p>\n
The vapour is flammable.<\/p>\n

Appearance of solution<\/h3>\n
To 10 mL add 10 mL of water R. The solution is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Acidity or alkalinity<\/h3>\n
To 5 mL add 5 mL of carbon dioxide-free water R, 0.15 mL of phenolphthalein solution R and 0.5 mL of 0.01 M sodium hydroxide. The solution is pink. Add 0.7 mL of 0.01 M hydrochloric acid and 0.05 mL of methyl red solution R. The solution is red or orange.<\/p>\n

Relative density (2.2.5)<\/h4>\n
0.790 to 0.793.<\/p>\n

Reducing substances<\/h3>\n
To 30 mL add 0.1 mL of 0.02 M potassium permanganate and allow to stand in the dark for 2 h. The mixture is not completely decolourised.<\/p>\n

Matter insoluble in water<\/h3>\n
Dilute 1.0 mL to 20 mL with water R. The solution is clear (2.2.1).<\/p>\n

Residue on evaporation<\/h3>\n
Maximum 50 ppm.<\/p>\n
Evaporate 20.0 g to dryness on a water-bath and dry at 100-105 \u00b0C. The residue weighs a maximum of 1 mg.<\/p>\n

Water (2.5.12)<\/h4>\n
Maximum 3 g\/L, determined on 10.0 mL.<\/p>\n

STORAGE<\/h2>\n
Protected from light.<\/p>\n