(Ph. Eur. monograph 0003)<\/p>\n
9.5 per cent m\/m to 10.5 per cent m\/m of HCl (Mr 36.46).<\/p>\n
To 726 g of water R add 274 g of concentrated hydrochloric acid and mix.<\/p>\n
A. It is strongly acid (2.2.4).<\/p>\n
B. It gives reaction (a) of chlorides (2.3.1).<\/p>\n
C. It complies with the limits of the assay.<\/p>\n
It is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n
Maximum 1 ppm.<\/p>\n
To 60 mL add 50 mL of carbon dioxide-free water R, 1 mL of a 100 g\/L solution of potassium iodide R and 0.5 mL of iodide- free starch solution R. Allow to stand in the dark for 2 min. Any blue colour disappears on the addition of 0.2 mL of 0.01 M sodium thiosulfate.<\/p>\n
Maximum 5 ppm.<\/p>\n
To 26 mL add 10 mg of sodium hydrogen carbonate R and evaporate to dryness on a water-bath. Dissolve the residue in 15 mL of distilled water R.<\/p>\n
Maximum 0.01 per cent.<\/p>\n
Evaporate 100.0 g to dryness on a water-bath or using a rotary evaporator and dry the residue at 100-105 \u00b0C. The residue weighs a maximum of 10 mg.<\/p>\n
To 6.00 g add 30 mL of water R. Titrate with 1 M sodium hydroxide, determining the end-point potentiometrically (2.2.20).<\/p>\n
1 mL of 1 M sodium hydroxide is equivalent to 36.46 mg of HCl.<\/p>\n","protected":false},"excerpt":{"rendered":"
(Ph. Eur. monograph 0003) DEFINITION Content 9.5 per cent m\/m to 10.5 per cent m\/m of HCl (Mr 36.46). PREPARATION To 726 g of water R add 274 g of concentrated hydrochloric acid and mix. IDENTIFICATION A. It is strongly acid (2.2.4). B. It gives reaction (a) of chlorides (2.3.1). C. It complies with the…<\/p>\n","protected":false},"author":2,"featured_media":10694,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-10691","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=10691"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10691\/revisions"}],"predecessor-version":[{"id":10696,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10691\/revisions\/10696"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/10694"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=10691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=10691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=10691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}