{"id":10568,"date":"2025-10-08T10:42:58","date_gmt":"2025-10-08T03:42:58","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=10568"},"modified":"2025-10-08T10:42:58","modified_gmt":"2025-10-08T03:42:58","slug":"diethylamine-salicylate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/diethylamine-salicylate\/","title":{"rendered":"Diethylamine Salicylate"},"content":{"rendered":"

C_{11<\/sub>H_{17<\/sub>NO_{3<\/sub>\u00a0 \u00a0 \u00a0 \u00a0211.3\u00a0 \u00a0 \u00a0 \u00a04419-92-5<\/p>\n}}}

Action and use<\/strong><\/p>\n

Counter-irritant.<\/p>\n

Preparation<\/strong><\/p>\n

Diethylamine Salicylate Cream<\/p>\n

DEFINITION<\/h2>\n
Diethylamine Salicylate contains not less than 99.0% and not more than 101.0% of C11H17NO3.<\/p>\n
CHARACTERISTICS<\/h2>\n
White or almost white crystals.<\/p>\n
Very soluble in water; freely soluble in ethanol (96%).<\/p>\n
IDENTIFICATION<\/h2>\n
A. The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of diethylamine salicylate (RS 099).<\/p>\n
B. To 0.2 g add 5 mL of 1M sodium hydroxide, heat to boiling point, cool and acidify with 2M hydrochloric acid; a white precipitate is produced. The melting point of the precipitate, after recrystallisation from water and drying at 105\u00b0, is about 160\u00b0, Appendix V A.<\/p>\n
TESTS<\/h2>\n
Acidity<\/h3>\n
Dissolve 2 g in 25 mL of water and titrate with 0.1M sodium hydroxide VS using phenol red solution as indicator. Not more than 0.2 mL of 0.1M sodium hydroxide VS is required to change the colour of the solution.<\/p>\n
Clarity and colour of solution<\/h3>\n
A 50% w\/v solution is clear, Appendix IV A, and not more intensely coloured than reference solution BY5, Appendix IV B,<\/p>\n
Method II.<\/p>\n
Melting point<\/h3>\n
100\u00b0 to 102\u00b0, Appendix V A.<\/p>\n
Sulfate<\/h3>\n
0.6 g complies with the limit test for sulfates, Appendix VII (250 ppm).<\/p>\n
Loss on drying<\/h4>\n
When dried at 60\u00b0 for 3 hours, loses not more than 0.1% of its weight. Use 1 g.<\/p>\n
ASSAY<\/h2>\n
Carry out Method I for non-aqueous titration, Appendix VIII A, using 0.4 g and 1-naphtholbenzein solution as indicator.<\/p>\n
Each mL of 0.1M perchloric acid VS is equivalent to 21.13 mg of C_{11<\/sub>H_{17<\/sub>NO_{3<\/sub>.<\/p>\n}}}
STORAGE<\/h2>\n
Diethylamine Salicylate should be protected from light. It should not be allowed to come into contact with iron or iron salts.<\/p>\n","protected":false},"excerpt":{"rendered":"
C11H17NO3\u00a0 \u00a0 \u00a0 \u00a0211.3\u00a0 \u00a0 \u00a0 \u00a04419-92-5 Action and use Counter-irritant. Preparation Diethylamine Salicylate Cream DEFINITION Diethylamine Salicylate contains not less than 99.0% and not more than 101.0% of C11H17NO3. CHARACTERISTICS White or almost white crystals. Very soluble in water; freely soluble in ethanol (96%). IDENTIFICATION A. The infrared absorption spectrum, Appendix II A, is…<\/p>\n","protected":false},"author":2,"featured_media":10585,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-10568","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=10568"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10568\/revisions"}],"predecessor-version":[{"id":10588,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10568\/revisions\/10588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/10585"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=10568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=10568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=10568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

CHARACTERISTICS<\/h2>\nWhite or almost white crystals.<\/p>\nVery soluble in water; freely soluble in ethanol (96%).<\/p>\n

TESTS<\/h2>\n

Acidity<\/h3>\nDissolve 2 g in 25 mL of water and titrate with 0.1M sodium hydroxide VS using phenol red solution as indicator. Not more than 0.2 mL of 0.1M sodium hydroxide VS is required to change the colour of the solution.<\/p>\n

Clarity and colour of solution<\/h3>\nA 50% w\/v solution is clear, Appendix IV A, and not more intensely coloured than reference solution BY5, Appendix IV B,<\/p>\nMethod II.<\/p>\n

Melting point<\/h3>\n100\u00b0 to 102\u00b0, Appendix V A.<\/p>\n

Sulfate<\/h3>\n0.6 g complies with the limit test for sulfates, Appendix VII (250 ppm).<\/p>\n

Loss on drying<\/h4>\nWhen dried at 60\u00b0 for 3 hours, loses not more than 0.1% of its weight. Use 1 g.<\/p>\n

ASSAY<\/h2>\nCarry out Method I for non-aqueous titration, Appendix VIII A, using 0.4 g and 1-naphtholbenzein solution as indicator.<\/p>\nEach mL of 0.1M perchloric acid VS is equivalent to 21.13 mg of C11<\/sub>H17<\/sub>NO3<\/sub>.<\/p>\n

CHARACTERISTICS<\/h2>\n
White or almost white crystals.<\/p>\n
Very soluble in water; freely soluble in ethanol (96%).<\/p>\n

Acidity<\/h3>\n
Dissolve 2 g in 25 mL of water and titrate with 0.1M sodium hydroxide VS using phenol red solution as indicator. Not more than 0.2 mL of 0.1M sodium hydroxide VS is required to change the colour of the solution.<\/p>\n

Clarity and colour of solution<\/h3>\n
A 50% w\/v solution is clear, Appendix IV A, and not more intensely coloured than reference solution BY5, Appendix IV B,<\/p>\n
Method II.<\/p>\n

Melting point<\/h3>\n
100\u00b0 to 102\u00b0, Appendix V A.<\/p>\n

Sulfate<\/h3>\n
0.6 g complies with the limit test for sulfates, Appendix VII (250 ppm).<\/p>\n

Loss on drying<\/h4>\n
When dried at 60\u00b0 for 3 hours, loses not more than 0.1% of its weight. Use 1 g.<\/p>\n

ASSAY<\/h2>\n
Carry out Method I for non-aqueous titration, Appendix VIII A, using 0.4 g and 1-naphtholbenzein solution as indicator.<\/p>\n
Each mL of 0.1M perchloric acid VS is equivalent to 21.13 mg of C_{11<\/sub>H_{17<\/sub>NO_{3<\/sub>.<\/p>\n}}}