{"id":10267,"date":"2025-10-07T15:26:00","date_gmt":"2025-10-07T08:26:00","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=10267"},"modified":"2025-10-07T15:26:00","modified_gmt":"2025-10-07T08:26:00","slug":"dextranomer","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/dextranomer\/","title":{"rendered":"Dextranomer"},"content":{"rendered":"

(Ph. Eur. monograph 2238)<\/p>\n

56087-11-7<\/p>\n

Action and use<\/strong><\/p>\n

Fluid absorber; treatment of burns, wounds and skin ulcers; preparation for skin grafting.<\/p>\n

DEFINITION<\/h2>\n

Three-dimensional network made of dextran chains O,O\u2032-cross-linked with 2-hydroxypropane-1,3-diyl bridges and O- substituted with 2,3-dihydroxypropyl and 2-hydroxy-1-(hydroxymethyl)ethyl groups.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white, spherical beads.<\/p>\n

Solubility<\/h3>\n

Practically insoluble in water. It swells in water and in electrolyte solutions.<\/p>\n

PRODUCTION<\/h2>\n

The absorption capacity is determined using a 9.0 g\/L solution of sodium chloride R containing 20 \u03bcL\/L of polysorbate 20 R or another suitable solution, with a suitable, validated method.<\/p>\n

The particle size is controlled to a minimum of 80 per cent of the number of dry beads within 100-300 \u03bcm and a maximum of 7 per cent of their number below 100 \u03bcm using a suitable, validated method.<\/p>\n

IDENTIFICATION<\/h2>\n

A. The substance to be examined is practically insoluble in water R. It swells in water R.<\/p>\n

B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n

Preparation: Grind the substance to be examined in acetone R. Evaporate the solvent at room temperature and use the residue.<\/p>\n

Comparison: dextranomer CRS.<\/p>\n

TESTS<\/h2>\n

pH (2.2.3)<\/h3>\n

5.3 to 7.5.<\/p>\n

Introduce 0.50 g to 30 mL of a freshly prepared 74.6 g\/L solution of potassium chloride R. Allow to stand for 2 min.<\/p>\n

Determine the pH on the mucilage obtained.<\/p>\n

Boron<\/h3>\n

Maximum 30 ppm.<\/p>\n

Inductively coupled plasma-atomic emission spectrometry (ICP-AES) (2.2.57).<\/p>\n

Test solution: Introduce 3.0 g into a platinum dish and moisten with 5 mL of a 32.1 g\/L solution of magnesium nitrate R in a mixture of equal volumes of ethanol (96 per cent) R and distilled water R. Evaporate to dryness on a water-bath. Ignite at 550 \u00b0C for 5 h. Take up the residue with 5 mL of 6 M hydrochloric acid R and transfer to a 50 mL volumetric flask. Add about 20 mL of distilled water R and allow to digest for 1 h on a water-bath. Allow to cool and dilute to 50.0 mL with distilled
\nwater R.<\/p>\n

Reference solutions: Prepare the reference solutions using a solution of boric acid R containing 10 ppm of boron. Proceed as described for the test solution.<\/p>\n

Wavelength: 249.773 nm.<\/p>\n

Loss on drying (2.2.32)<\/h4>\n

Maximum 10.0 per cent, determined on 1.000 g by drying in an oven at 105 \u00b0C for 15 h.<\/p>\n

Sulfated ash (2.4.14)<\/h4>\n

Maximum 0.4 per cent, determined on 1.0 g.<\/p>\n

Microbial contamination<\/h3>\n

TAMC: acceptance criterion 10 CFU\/g (2.6.12), determined using the pour-plate method.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 2238) 56087-11-7 Action and use Fluid absorber; treatment of burns, wounds and skin ulcers; preparation for skin grafting. DEFINITION Three-dimensional network made of dextran chains O,O\u2032-cross-linked with 2-hydroxypropane-1,3-diyl bridges and O- substituted with 2,3-dihydroxypropyl and 2-hydroxy-1-(hydroxymethyl)ethyl groups. CHARACTERS Appearance White or almost white, spherical beads. Solubility Practically insoluble in water. It swells…<\/p>\n","protected":false},"author":2,"featured_media":10282,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-10267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=10267"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10267\/revisions"}],"predecessor-version":[{"id":10284,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/10267\/revisions\/10284"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/10282"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=10267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=10267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=10267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}